NEDD4-1 (H-135) Antibody: sc-25508

NEDD4-1 Background Information
NEDD4 is an E3 ubiquitin-protein ligase that contains several family members including NEDD4-1 and NEDD4-2, both of which are HECT-type E3 ligases with similar structure and function. Located primarily in muscle fibers, NEDD4 is a ubiquitin acceptor that transports ubiquitin from E2 ligase enzymes to various substrates throughout the body, helping to regulate degradation of plasma membranes. Thought to play a role in the budding of many retroviruses, NEDD4 interacts with the viral protein motif P-P-P-Y, an interaction that is important for viral maturation. NEDD4 contains three WW domains to which many ubiquitin-receiving proteins, including NEDD4 family interacting protein-1 (NDFIP1), bind and interact. NDFIP1 is strongly expressed in surviving neurons around a site of injury, suggesting that ubiquitination may be a possible survival strategy and NDFIP1 may act as a neuroprotective protein.