Molecular structure of Azithromycin, CAS Number: 83905-01-5
Azithromycin (CAS 83905-01-5)
See product citations (17)
Alternate Names:
CP 62993
Application:
Azithromycin is an azalide macrolide antibiotic
CAS Number:
83905-01-5
Purity:
958 ug/mg
Molecular Weight:
748.98
Molecular Formula:
C38H72N2O12
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Azithromycin is an azalide antibiotic, which inhibits the growth of gram negative bacteria, such as Haemophilus influenza. Azithromycin functions by interfering with 50S ribosomal subunit formation and translation, which inhibits the formation of proteins essential for bacterial survival. Studies involving capillary electrophoresis suggest that Azithromycin can be used as a chiral selector for enantiomeric separation of compounds. In addition, Azithrmycin can be used to increase chloride efflux and selectively reduces tumor necrosis factor alpha in human cystic fibrosis cells. Furthermore, Azithromycin reduces LPS-induced pulmonary neutrophilia in mice, via suppressing the expression of IL-1beta.
Azithromycin (CAS 83905-01-5) References
- Macrolides and ketolides: azithromycin, clarithromycin, telithromycin. | Zuckerman, JM. 2004. Infect Dis Clin North Am. 18: 621-49, xi-. PMID: 15308279
- Structure-activity relationships for three macrolide antibiotics in Haemophilus influenzae. | Mabe, S., et al. 2004. Curr Microbiol. 49: 248-54. PMID: 15386112
- Azithromycin selectively reduces tumor necrosis factor alpha levels in cystic fibrosis airway epithelial cells. | Cigana, C., et al. 2007. Antimicrob Agents Chemother. 51: 975-81. PMID: 17210769
- Restoration of chloride efflux by azithromycin in airway epithelial cells of cystic fibrosis patients. | Saint-Criq, V., et al. 2011. Antimicrob Agents Chemother. 55: 1792-3. PMID: 21220528
- Azithromycin as a new chiral selector in capillary electrophoresis. | Kumar, AP. and Park, JH. 2011. J Chromatogr A. 1218: 1314-7. PMID: 21256503
- Non-surgical periodontal therapy supplemented with systemically administered azithromycin: a systematic review of RCTs. | Buset, SL., et al. 2015. Clin Oral Investig. 19: 1763-75. PMID: 26063646
- Azithromycin for the Prevention of COPD Exacerbations: The Good, Bad, and Ugly. | Taylor, SP., et al. 2015. Am J Med. 128: 1362.e1-6. PMID: 26291905
- Use and safety of azithromycin in neonates: a systematic review. | Smith, C., et al. 2015. BMJ Open. 5: e008194. PMID: 26656010
- Azithromycin administered for acute bronchiolitis may have a protective effect on subsequent wheezing. | Luisi, F., et al. 2020. J Bras Pneumol. 46: e20180376. PMID: 32130359
- Immunomodulation Mediated by Azithromycin in Experimental Periapical Inflammation. | Andrada, AC., et al. 2020. J Endod. 46: 1648-1654. PMID: 32763436
- Azithromycin: The First Broad-spectrum Therapeutic. | Firth, A. and Prathapan, P. 2020. Eur J Med Chem. 207: 112739. PMID: 32871342
- Retargeting azithromycin analogues to have dual-modality antimalarial activity. | Burns, AL., et al. 2020. BMC Biol. 18: 133. PMID: 32993629
- Azithromycin Protects Oligodendrocyte Progenitor Cells against Lipopolysaccharide-Activated Microglia-Induced Damage. | Ramarao, S., et al. 2022. Dev Neurosci. 44: 1-12. PMID: 34571509
- Azithromycin alleviates the severity of rheumatoid arthritis by targeting the unfolded protein response component of glucose-regulated protein 78 (GRP78). | Zhang, Y., et al. 2022. Br J Pharmacol. 179: 1201-1219. PMID: 34664264
- Hydroxychloroquine and azithromycin used alone or combined are not effective against SARS-CoV-2 ex vivo and in a hamster model. | Cochin, M., et al. 2022. Antiviral Res. 197: 105212. PMID: 34838583
Inhibitor of:
ATP6V0E1, Bordetella, Bordetella pertussis, Borrelia burgdorferi Osp A, Brucella abortus, Brucella abortus LPS, C. trachomatis, C. trachomatis MOMP, Chlamydia LPS, CRS4C-5, cryptdin 22, DC-SIGN/CD209, Edwardsiella tarda, Enrofloxacin, FAM96B, Francisella tularensis LPS, Gonorrhea, GRAMD2, GTPBP5, H. influenzae B, IARS2, ICT1, IL-8RA, Legionella pneumophila LPS, Lipid A, motilin, MRP-63, MRP-L1, MRP-L33, MRP-L46, MRP-L54, Mycoplasma, Pseudomonas aeruginosa, Ribosomal Protein L24, Ribosomal Protein L27a, Ribosomal Protein L28, Ribosomal Protein L36aL, Ribosomal Protein S26, Rpp14, Salmonella (Enterobacterales), Salmonella O, Salmonella paratyphi 0-2, Salmonella typhimurium 0-4, SBDS, Shigella dysenteriae, Sigma 54, SP-C, and Toxoplasma gondii.Activator of:
Alphavirus, Aspergillus, Coronavirus nucleocapsid, Diphtheria Toxin, EF-2, H2-Abβ, H2-M1, KSHV ORF 45, La Crosse Virus G1, LETM1, MRP-L11, MRP-L22, MRP-S18B, MRP-S25, NYD-SP29, Ribosomal Protein L15, Ribosomal Protein L35, Ribosomal Protein L6, RRP8, Shigatoxin, St. Louis encephalitis, and VCC-1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Azithromycin, 25 mg | sc-254949 | 25 mg | $51.00 | |||
Azithromycin, 50 mg | sc-254949A | 50 mg | $101.00 | |||
Azithromycin, 500 mg | sc-254949B | 500 mg | $255.00 | |||
Azithromycin, 1 g | sc-254949C | 1 g | $357.00 | |||
Azithromycin, 5 g | sc-254949D | 5 g | $714.00 |