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home » Membrane Receptors » EDG-8 Antibody / EDG-8 Antibodies » EDG-8 (H-88): sc-25493

EDG-8 (H-88) Antibody: sc-25493

  |  Datasheet
  • rabbit polyclonal IgG, 200 µg/ml
  • epitope corresponding to amino acids 311-398 mapping at the C-terminus of EDG-8 of human origin
  • recommended for detection of EDG-8 of human and, to a lesser extent, mouse and rat origin by WB, IP, IF and ELISA
 
Additional EDG-8 Antibodies ...
 
Ordering Information
Recommended Support Products:
(click button of application of choice)
WB   IP   IF   siRNA  
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human EDG8 53637 19p13.2 NM_030760 Q9H228
 605146
Mouse S1pr5 94226 9 A3 Q91X56
 N/A
Mouse S1pr5 94226 9 A3 Q91X56
 N/A
 
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
EDG-8 (H-88) sc-25493 200 µg/ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
EDG-8 siRNA (h) sc-39930 10 µM $258
EDG-8 (h)-PR sc-39930-PR 10 µM $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
EDG-8 shRNA Plasmid (h) sc-39930-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
EDG-8 shRNA (h) Lentiviral Particles sc-39930-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
HeLa Whole Cell Lysate sc-2200 500 µg/200 µl $104
EDG-8 (h): 293T Lysate sc-113850 100µg/200µl $205
Hep G2 Cell Lysate sc-2227 500 µg/200 µl $104

EDG-8 Background Information
The EDG (endothelial differentiation gene) family of G protein coupled receptors consists of eight family members that bind lysophospholipid (LPL) mediators, including sphingosine-1-phosphate (SPP) and lysophosphatidic acid (LPA). EDG-1, EDG-3, EDG-5 (also designated H218 and AGR16) and EDG-8 bind SPP with high affinity. EDG-6 is a low affinity receptor for SPP. LPA preferentially binds to EDG-2, EDG-4 and EDG-7. The EDG receptors couple to multiple G proteins to signal through Ras, MAP kinase, Rho, Phospholipase C or other tyrosine kinases, which lead to cell survival, growth, migration and differentiation. EDG-1 signals through Gi proteins to activate Akt and is expressed in glioma cells. EDG-2 is expressed in brain, especially in white matter tract regions, while EDG-3 is expressed in cardiovascular tissue and in cerebellum. EDG-4 is highly expressed on leukocytes and brain, and EDG-5 has wide tissue distribution, including cardiovascular tissue and brain. EDG-6, which is expressed in lymphoid and hematopoietic tissues and in lung, signals through G(i/o) proteins, which activate growth related pathways.

EDG-8 (H-88)
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sc-25493
EDG-8 (H-88): sc-25493. Western blot analysis of EDG-8 expression in non-transfected 293T: sc-117752 (A), human EDG-8 transfected 293T: sc-113850 (B) and HeLa (C) whole cell lysates.
sc-25493
EDG-8 (H-88): sc-25493. Western blot analysis of EDG-8 expression in non-transfected: sc-117752 (A) and mouse EDG-8 transfected: sc-119921 (B) 293T whole cell lysates.
sc-25493
EDG-8 (H-88): sc-25493. Western blot analysis of EDG-8 expression in Hep G2 whole cell lysate.
sc-25493
EDG-8 (H-88): sc-25493. Immunofluorescence staining of formalin-fixed Hep G2 cells showing membrane localization.
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