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home » Membrane Receptors » EDG-4 Antibody / EDG-4 Antibodies » EDG-4 (H-55): sc-25490

EDG-4 (H-55) Antibody: sc-25490

  |  Datasheet
  • rabbit polyclonal IgG, 200 µg/ml
  • epitope corresponding to amino acids 131-185 mapping near the N-terminus of EDG-4 of human origin
  • recommended for detection of EDG-4 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
 
Additional EDG-4 Antibodies ...
 
Ordering Information
Recommended Support Products:
(click button of application of choice)
WB   IP   IF   siRNA  
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human EDG4 9170 19p13.11 NM_004720 Q9HBW0
 605110
Mouse Lpar2 53978 8 B3.3 Q9JL06
 N/A
 
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
EDG-4 (H-55) sc-25490 200 µg/ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
EDG-4 siRNA (h) sc-39926 10 µM $258
EDG-4 siRNA (m) sc-39927 10 µM $258
EDG-4 (h)-PR sc-39926-PR 10 µM $23
EDG-4 (m)-PR sc-39927-PR 10 µM $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
EDG-4 shRNA Plasmid (h) sc-39926-SH 20 µg $520
EDG-4 shRNA Plasmid (m) sc-39927-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
EDG-4 shRNA (h) Lentiviral Particles sc-39926-V 200 µl $625
EDG-4 shRNA (m) Lentiviral Particles sc-39927-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
BT-20 Cell Lysate sc-2223 500 µg/200 µl $104
MDA-MB-231 Cell Lysate sc-2232 500 µg/200 µl $104
ES-2 Cell Lysate sc-24674 500 µg/200 µl $104
CHO-K1 Cell Lysate sc-3809 500 µg/200 µl $104

EDG-4 Background Information
The EDG (endothelial differentiation gene) family of G protein coupled receptors consists of eight family members that bind lysophospholipid (LPL) mediators, including sphingosine-1-phosphate (SPP) and lysophosphatidic acid (LPA). EDG-1, EDG-3, EDG-5 (also designated H218 and AGR16) and EDG-8 bind SPP with high affinity. EDG-6 is a low affinity receptor for SPP. LPA preferentially binds to EDG-2, EDG-4 and EDG-7. The EDG receptors couple to multiple G proteins to signal through Ras, MAP kinase, Rho, Phospholipase C or other tyrosine kinases, which lead to cell survival, growth, migration and differentiation. EDG-1 signals through Gi proteins to activate Akt and is expressed in glioma cells. EDG-2 is expressed in brain, especially in white matter tract regions, while EDG-3 is expressed in cardiovascular tissue and in cerebellum. EDG-4 is highly expressed on leukocytes and brain, and EDG-5 has wide tissue distribution, including cardiovascular tissue and brain. EDG-6, which is expressed in lymphoid and hematopoietic tissues and in lung, signals through G(i/o) proteins, which activate growth related pathways.

EDG-4 (H-55)
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sc-25490
EDG-4 (H-55): sc-25490. Western blot analysis of EDG-4 expression in BT-20 (A), MDA-MB-231 (B), ES-2 (C), OV-90 (D) and CHO-K1 (E) whole cell lysates.
sc-25490
EDG-4 (H-55): sc-25490. Western blot analysis of EDG-4 expression in BT-20 (A), MDA-MB-231 (B), CHO-K1 (C) and OV-90 (D) whole cell lysates.
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