megalin (H-245) Antibody: sc-25470

megalin Background Information
Members of the LDL receptor gene family, including LDLR (low density lipo-protein receptor), LRP (low density lipoprotein related protein), megalin (also designated GP330), VLDLR (very low density lipoprotein receptor) and ApoER2, are characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats and an O-linked sugar domain. Megalin is expressed on the apical membrane domain of epithelial cells, including proximal kidney tubules, intestine and ependymal cells. Proper folding and trafficking of megalin is facilitated by the receptor-associated protein (RAP), a molecular chaperone that can block the uptake of all known ligands for megalin. Specifically, megalin mediates the uptake of apolipoprotein J (apoJ, also designated Clusterin), which is a binding protein for the b-Amyloid peptide, a peptide implicated in Alzheimer’s disease. Megalin is also an antigenic determinant for Heymann nephritis in rats and may be important in the reabsorption of several molecules, including vitamin B12, in the kidney.