RXR (DR-1) Gel Shift Oligonucleotides: sc-2547

RXR (DR-1) Gel Shift Oligonucleotides are short sequences of DNA meticulously designed for use in gel shift assays, a foundational technique in molecular biology research aimed at studying protein-DNA interactions. The name "RXR (DR-1)" refers to the retinoid X receptor (RXR) and the direct repeat 1 (DR-1) motif, which is the consensus binding sequence recognized by RXR. RXR is a member of the nuclear receptor superfamily and serves as a versatile transcription factor that regulates gene expression in response to various ligands, including retinoids and fatty acids. Upon ligand binding, RXR forms heterodimers with other nuclear receptors, such as retinoic acid receptors (RARs), peroxisome proliferator-activated receptors (PPARs), and vitamin D receptors (VDRs), and binds to specific DNA sequences, such as the DR-1 motif, within the promoters of target genes. By utilizing RXR (DR-1) Gel Shift Oligonucleotides in gel shift assays, researchers can investigate the binding kinetics, specificity, and affinity of RXR heterodimers to DR-1 motifs under various experimental conditions. This technique facilitates the elucidation of the molecular mechanisms underlying RXR-mediated gene regulation and provides insights into the complex signaling networks that govern cellular responses to retinoid and lipid signaling.

RXR (DR-1) Gel Shift Oligonucleotides References:

1. All-trans-retinoic acid inhibition of Pro alpha1(I) collagen gene expression in fetal rat skin fibroblasts: identification of a retinoic acid response element in the Pro alpha1(I) collagen gene.  |  Meisler, NT., et al. 1997. J Invest Dermatol. 108: 476-81. PMID: 9077477