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Salinomycin (CAS 53003-10-4)

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Application:A polyether potassium ionophore
CAS Number:53003-10-4
Purity:≥95%
Molecular Weight:751.00
Molecular Formula:C42H70O11
Refer to Certificate of Analysis for lot specific data (including water content).
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
Salinomycin sc-253530 5 mg $150
Salinomycin sc-253530A 25 mg $510
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
Description
Salinomycin is a polyether potassium ionophore antibiotic, which promotes cation movement across biological membranes via exchange-diffusion. As a result of this cation exchange, the transmembrane gradients are altered, which leads to changes in cellular function and metabolism. In addition, Salinomycin acts as a chelating agent towards monovalent cations such as sodium and potassium ions. Alternate studies suggest that Salinomycin selectively inhibits cancer stem-like cells.
Technical Information
Appearance:Powder
Physical State:Solid
Derived from:Streptomyces albus
Solubility:Solubility: Soluble in methanol (10 mg/mL)
Storage:Store at -20° C
Melting Point:112.5-113.5 lit
Safety and Reference Information
Transport:UN 3462, Class 6.1, Packing group II
PubChem CID:72370
MDL Number:MFCD00865281
EC Number:258-290-1
SMILES:CCC(C1CCC(C(O1)C(C)C(C(C)C(=O)C(CC)C2C(CC(C3(O2)C=CC(C4(O3)CCC(O4)(C)C5CCC(C (O5)C)(CC)O)O)C)C)O)C)C(=O)O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
References
1. Dong, T.T., et al. 2011. Ann Surg Oncol. [Epub ahead of print]. PMID: 21267784
2. Wang, Y. 2011. Med Chem. [Epub ahead of print]. PMID: 21222617
SDS (MSDS)
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