Date published: 2026-8-17

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Nomifensine maleate salt (CAS 32795-47-4)

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CAS Number:
32795-47-4
Purity:
≥97%
Molecular Weight:
354.40
Molecular Formula:
C16H18N2•C4H4O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Nomifensine maleate salt is a compound that functions as a potent and selective inhibitor of the neuronal reuptake of dopamine. It acts by binding to the dopamine transporter and preventing the reuptake of dopamine into presynaptic neurons, leading to an increase in dopamine levels in the synaptic cleft. This increase in dopamine concentration enhances dopaminergic neurotransmission, which may have implications for studying the role of dopamine in various physiological and pathological processes. At the molecular level, Nomifensine maleate salt modulates the activity of dopamine receptors and influences downstream signaling pathways, potentially affecting cellular responses and behaviors. Its mechanism of action involves specific interactions with dopaminergic systems, making it useful for investigating the role of dopamine in neurobiology and related fields.

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

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Nomifensine maleate salt (CAS 32795-47-4) References

  1. Spectrophotometric and fluorimetric determination of nomifensine maleate.  |  Wahbi, AA., et al. 1987. Talanta. 34: 287-9. PMID: 18964297
  2. Intra-median raphe infusions of muscimol and the substance P analogue DiMe-C7 produce hyperactivity: role of serotonin neurons.  |  Paris, JM. and Lorens, SA. 1987. Behav Brain Res. 26: 139-51. PMID: 2447909
  3. Colorimetric methods for the assay of nomifensine maleate.  |  Abounassif, MA., et al. 1989. J Pharm Biomed Anal. 7: 23-8. PMID: 2488604
  4. Plasticity in striatal dopamine release is governed by release-independent depression and the dopamine transporter.  |  Condon, MD., et al. 2019. Nat Commun. 10: 4263. PMID: 31537790
  5. Role of Prefrontal Cortex on Recognition Memory Deficits in Rats following 6-OHDA-Induced Locus Coeruleus Lesion.  |  Sampaio, TB., et al. 2020. Oxid Med Cell Longev. 2020: 8324565. PMID: 32733637
  6. Intracerebral Administration of a Ligand-ASO Conjugate Selectively Reduces α-Synuclein Accumulation in Monoamine Neurons of Double Mutant Human A30P*A53T*α-Synuclein Transgenic Mice.  |  Pavia-Collado, R., et al. 2021. Int J Mol Sci. 22: PMID: 33805843
  7. Striatal Dopamine Transporter Function Is Facilitated by Converging Biology of α-Synuclein and Cholesterol.  |  Threlfell, S., et al. 2021. Front Cell Neurosci. 15: 658244. PMID: 33935654
  8. Blockade of Catecholamine Reuptake in the Prelimbic Cortex Decreases Top-down Attentional Control in Response to Novel, but Not Familiar Appetitive Distracters, within a Timing Paradigm.  |  Matthews, AR., et al. 2020. NeuroSci. 1: 99-114. PMID: 35036990
  9. Up and Down γ-Synuclein Transcription in Dopamine Neurons Translates into Changes in Dopamine Neurotransmission and Behavioral Performance in Mice.  |  Pavia-Collado, R., et al. 2022. Int J Mol Sci. 23: PMID: 35163729
  10. Enhancer Regulation of Dopaminergic Neurochemical Transmission in the Striatum.  |  Harsing, LG., et al. 2022. Int J Mol Sci. 23: PMID: 35955676
  11. Diarrhea and lethal bone marrow depression induced by nomifensine maleate.  |  Mosseri, M., et al. 1987. Isr J Med Sci. 23: 906. PMID: 3679796
  12. Evidence for a permanent decline in tuberoinfundibular dopaminergic neuronal function after chronic estrogen treatment is terminated in Fischer 344 rats.  |  Gottschall, PE. and Meites, J. 1986. Neuroendocrinology. 44: 211-6. PMID: 3796794
  13. Effects of dopamine uptake inhibitors on schedule-controlled behavior in the squirrel monkey.  |  McKearney, JW. 1982. Psychopharmacology (Berl). 78: 377-9. PMID: 6818602
  14. Effects of nomifensine (HOE 984) upon psychomotor activity and intracranial self-stimulation in the rat.  |  Katz, RJ., et al. 1977. Pharmacol Biochem Behav. 7: 269-72. PMID: 928482

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Nomifensine maleate salt, 100 mg

sc-253197
100 mg
$214.00

Nomifensine maleate salt, 250 mg

sc-253197A
250 mg
$364.00

Nomifensine maleate salt, 500 mg

sc-253197B
500 mg
$624.00