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- rabbit polyclonal IgG, 200 µg/ml; also available as goat IgG, 200 µg/ml, sc-253-G
- epitope mapping within an internal region of c-Fos of human origin
- recommended for detection of c-Fos, Fos B, Fra-1 and Fra-2 of mouse, rat, human, Xenopus and zebrafish origin by WB, IP, IF, IHC(P), FCM and ELISA; also reactive with additional species, including equine, canine, bovine, porcine, avian and feline
- blocking peptide, sc-253 P
- agarose conjugate for IP studies, sc-253 AC, 500 µg/0.25 ml agarose
- fluorescein (sc-253 FITC) and rhodamine (sc-253 TRITC) conjugates for immunofluorescence, 200 µg/ml
- phycoerythrin conjugate for intracellular FCM, sc-253 PE, 100 tests
- HRP conjugate, sc-253 HRP, 200 µg/ml
- TransCruz reagent for Gel Supershift and ChIP applications, sc-253 X, 200 µg/0.1 ml
- Alexa Fluor® 405 (sc-253 AF405), Alexa Fluor® 488 (sc-253 AF488) and Alexa Fluor® 647 (sc-253 AF647) conjugates for FCM or immunofluorescence; 100 µg/2 ml
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c-Fos Background Information
The c-Fos oncogene was initially detected in two independent murine osteosarcoma virus isolates and an avian nephroblastoma virus. The cellular homolog, c-Fos, encodes a nuclear phospho-protein that is rapidly and transiently induced by a variety of agents and functions as a transcriptional regulator for several genes. In contrast to c-Jun proteins, which form homo- and heterodimers which bind to specific DNA response elements, c-Fos proteins are only active as heterodimers with members of the Jun gene family. Functional homologs of c-Fos include the Fra-1, Fra-2 and Fos B genes. In addition, selected ATF/CREB family members can form leucine zipper dimers with Fos and Jun. Different dimers exhibit differential specificity and affinity for AP-1 and CRE sites.
| c-Fos (K-25) Product Citations |
See how others have used c-Fos (K-25): sc-253 antibody and or c-Fos (K-25) antibody conjugates.
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c-Fos (K-25)
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c-Fos (K-25) PE: sc-253 PE. Intracellular FCM analysis of fixed and permeabilized MIA PaCa-2a cells. Black line histogram represents the isotype control, normal rabbit IgG: sc-3871. c-Fos (K-25): sc-253. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human colon carcinoma tissue (A) and immunofluorescence staining of methanol-fixed A-431 cells (B) showing nuclear localization.
c-Fos (K-25): sc-253. Western blot analysis of Fos gene family protein expression in untreated (A) and PMA-treated (B) Jurkat nuclear extracts.
c-Fos (K-25): sc-253. Western blot analysis of Fos B expression in non-transfected: sc-117752 (A) and human Fos B transfected: sc-112170 (B) 293T whole cell lysates. c-Fos (K-25): sc-253. Western blot analysis of Fra-2 expression in non-transfected: sc-117752 (A) and human Fra-2 transfected: sc-176490 (B) 293T whole cell lysates. c-Fos (K-25): sc-253. Western blot analysis of Fra-2 expression in non-transfected: sc-117752 (A) and human Fra-2 transfected: sc-176490 (B) 293T whole cell lysates. c-Fos (K-25): sc-253. Western blot analysis of Fos B expression in non-transfected: sc-117752 (A) and human Fos B transfected: sc-177246 (B) 293T whole cell lysates. c-Fos (K-25): sc-253. Western blot analysis of Fra-2 expression in non-transfected: sc-117752 (A) and human Fra-2 transfected: sc-176435 (B) whole cell lysates. |
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