Tachykinin (H-2) Antibody: sc-25266

Tachykinin Background Information
The tachykinin family consists of amidated neuropeptides that share a carboxy-terminal sequence (Phe-X-Gly-Leu-Met-NH2). Preprotachykinin I, also designated protachykinin 1 precursor (PPT), is a common precursor of tachykinins. Preprotachykinin I alternately splices to form various isoforms. These isoforms include Substance P, Neurokinin A (NKA, Substance K, Neuromedin L), Neurokinin B, Neuropeptide K (NPK), Neuropeptide © and C-terminal flanking peptide. Substance P is expressesed primarily in the small diameter primary sensory fibers of the peripheral nervous system, and in the superficial dorsal horn of the spinal cord, the substantia nigra and the medial amygdaloid nucleus of the central nervous system. Tachykinin peptides have many plieotropic functions, including neurotransmission, immune/ hematopoietic modulation, angiogenesis and mitogenesis. Preprotachykinin I has been implicated in breast cancer and bone marrow metastasis. Substance P plays a role in depression.