AP-2α Gel Shift Oligonucleotides: sc-2513

AP-2α Gel Shift Oligonucleotides are short DNA sequences designed for utilization in gel shift assays, a foundational technique in molecular biology research for analyzing protein-DNA interactions. These oligonucleotides are crafted based on the consensus binding sequence of the AP-2α transcription factor, a member of the AP-2 family known for its crucial role in the regulation of gene expression during development and differentiation processes. AP-2α functions as a transcriptional activator or repressor by binding to specific DNA sequences, referred to as AP-2 binding sites, within the promoters of target genes. Through the use of AP-2α Gel Shift Oligonucleotides in gel shift assays, researchers can explore the binding kinetics, specificity, and affinity of AP-2α to its target DNA sequences under various experimental conditions. This technique facilitates the elucidation of the molecular mechanisms underlying AP-2α-mediated gene regulation and provides insights into the signaling networks governing cellular processes such as embryonic development, tissue homeostasis, and carcinogenesis.

AP-2α Gel Shift Oligonucleotides References:

1. Tumor-specific transcription factor binding to an activator protein-2/Sp1 element of the urokinase-type plasminogen activator receptor promoter in a first large series of resected gastrointestinal cancers.  |  Schewe, DM., et al. 2003. Clin Cancer Res. 9: 2267-76. PMID: 12796395
2. Combination analysis of activator protein-1 family members, Sp1 and an activator protein-2alpha-related factor binding to different regions of the urokinase receptor gene in resected colorectal cancers.  |  Schewe, DM., et al. 2005. Clin Cancer Res. 11: 8538-48. PMID: 16361535