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KCC1 Antibody (P-20): sc-25037

 |  Datasheet

(Based on data analysis)
  • KCC1 Antibody (P-20) is a goat polyclonal IgG provided at 200 µg/ml
  • epitope mapping at the N-terminus of KCC1 of human origin
  • recommended for detection of KCC1 of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
  • blocking peptide, sc-25037 P
 

See additional KCC Antibodies including KCC, KCC1, KCC2, KCC2b, KCC3 and KCC4.

Also see KCC Inhibitors for functional analysis of cellular responses to KCC.


Ordering InformationGene Info
Recommended Support Products:
(click button of application of choice)
WB   IF   siRNA  
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 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
KCC1 Antibody (P-20) sc-25037 200 µg/ml $279
KCC1 (P-20) P sc-25037 P
(peptide)
 100 µg/0.5 ml $61
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
KCC1 siRNA (h) sc-42604 10 µM $258
KCC1 siRNA (m) sc-42605 10 µM $258
KCC1 (h)-PR sc-42604-PR 10 µM, 20 µl $23
KCC1 (m)-PR sc-42605-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
KCC1 shRNA Plasmid (h) sc-42604-SH 20 µg $520
KCC1 shRNA Plasmid (m) sc-42605-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
KCC1 shRNA (h) Lentiviral Particles sc-42604-V 200 µl $625
KCC1 shRNA (m) Lentiviral Particles sc-42605-V 200 µl $625
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human SLC12A4 6560 16q22.1 NM_005072 Q9UP95
 604119
Mouse Slc12a4 20498 8 D3 Q9JIS8
 N/A
 

The four isoforms of potassium/chloride co-transport channels (KCC) belong to a superfamily of cation-chloride co-transporters involved in cell volume maintenance. Nitric oxide (NO) donors activate KCCs, while inhibitors of the cGMP pathway prevent NO donor activation. The ubiquitously expressed KCC1 contains 12 transmembrane domains with both cytoplasmic N and C terminal domains. KCC2 expression is limited to neuronal tissues by a restrictive element similar to the neuronal-restrictive silencing factor. In neurons, KCC2 expression is correlated with an inhibitory response to GABA, while the absence of KCC2 is necessary for an unusual excitatory response to GABA. Alterations of KCC2 expression in the inferior colliculus of rat brain may be related to seizure susceptibility. Conversely, KCC3 is not suspected to play a major role in epilepsy. The two splice variants of KCC3, KCC3a and KCC3b, are predominantly expressed in brain and kidney, respectively, while KCC4 is expressed in muscle, brain, lung, heart and kidney.