AP-1 Gel Shift Oligonucleotides: sc-2501

AP-1 Gel Shift Oligonucleotides are short sequences of DNA specifically designed for use in gel shift assays to study transcription factor binding. These oligonucleotides are typically derived from the consensus binding sequence of the AP-1 transcription factor, which is a dimeric complex formed by proteins belonging to the Jun and Fos families. The AP-1 transcription factor plays a crucial role in regulating gene expression in response to various cellular signals, including growth factors, cytokines, and environmental stressors. By utilizing AP-1 Gel Shift Oligonucleotides in gel shift assays, researchers can investigate the binding affinity and specificity of the AP-1 transcription factor to its target DNA sequences under different experimental conditions. This technique allows for the elucidation of the molecular mechanisms underlying gene regulation mediated by the AP-1 transcription factor and provides valuable insights into cellular signaling pathways and gene expression networks.

AP-1 Gel Shift Oligonucleotides References:

1. Cell-extracellular matrix interactions stimulate the AP-1 transcription factor in an integrin-linked kinase- and glycogen synthase kinase 3-dependent manner.  |  Troussard, AA., et al. 1999. Mol Cell Biol. 19: 7420-7. PMID: 10523630
2. IFN-gamma up-regulates IL-18 gene expression via IFN consensus sequence-binding protein and activator protein-1 elements in macrophages.  |  Kim, YM., et al. 2000. J Immunol. 165: 3198-205. PMID: 10975835
3. Estrogen receptor-mediated repression of human hepatic lipase gene transcription.  |  Jones, DR., et al. 2002. J Lipid Res. 43: 383-91. PMID: 11893774
4. Activator protein-1 activation in acute lung injury.  |  Guo, RF., et al. 2002. Am J Pathol. 161: 275-82. PMID: 12107112
5. Porphyromonas gingivalis induces receptor activator of NF-kappaB ligand expression in osteoblasts through the activator protein 1 pathway.  |  Okahashi, N., et al. 2004. Infect Immun. 72: 1706-14. PMID: 14977979
6. [Up-regulation of transcription factors NF-E2, c-jun and c-fos of AP-1 family induced by Panax Notoginosides in hematopoietic cells].  |  Gao, RL., et al. 2004. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 12: 16-9. PMID: 14989762
7. Arctigenin, a phenylpropanoid dibenzylbutyrolactone lignan, inhibits MAP kinases and AP-1 activation via potent MKK inhibition: the role in TNF-alpha inhibition.  |  Cho, MK., et al. 2004. Int Immunopharmacol. 4: 1419-29. PMID: 15313439
8. JunD attenuates phenylephrine-mediated cardiomyocyte hypertrophy by negatively regulating AP-1 transcriptional activity.  |  Hilfiker-Kleiner, D., et al. 2006. Cardiovasc Res. 71: 108-17. PMID: 16690042
9. Piperonyl butoxide activates c-Jun and ATF-2 in the hepatocytes of mice.  |  Muguruma, M., et al. 2008. Arch Toxicol. 82: 749-53. PMID: 18228000
10. Characterization of novel phorbol ester- and serum-responsive sequences of the rat ornithine decarboxylase gene promoter.  |  Mar, PK., et al. 1995. Mol Carcinog. 14: 240-50. PMID: 8519413
11. A downstream AP-1 element regulates in vitro lung transcription from the human pulmonary surfactant protein B promoter.  |  McWhinney, CD. 1996. DNA Cell Biol. 15: 519-29. PMID: 8756333
12. Seizure activity results in a rapid induction of nuclear factor-kappa B in adult but not juvenile rat limbic structures.  |  Rong, Y. and Baudry, M. 1996. J Neurochem. 67: 662-8. PMID: 8764593
13. Cyclosporin A enhances the calcium-dependent induction of AP-1 complex and c-fos mRNA in a T cell lymphoma.  |  Su, Q., et al. 1996. Biochem Biophys Res Commun. 229: 249-56. PMID: 8954114
14. Effects of protein kinase C alpha overexpression on A7r5 smooth muscle cell proliferation and differentiation.  |  Wang, S., et al. 1997. Exp Cell Res. 236: 117-26. PMID: 9344591
15. Effect of a low-calcium environment on EGF inducible AP-1 binding activity in osteoblastic MC3T3-E1 cells.  |  Deyama, A., et al. 1997. Nucleic Acids Symp Ser. 193-4. PMID: 9586065