p107 Background Information The human retinoblastoma gene product plays an important role in the negative regulation of cell proliferation. Functional inactivation of Rb can be mediated either through mutation or as a consequence of interaction with DNA tumor virus encoded proteins. pRb and the structurally related p107 form complexes with E2F, a transcription factor originally identified through its role in transcriptional activation of the adenovirus E2 promoter. Moreover, pRB and p107 share a high degree of structural homology in the adenovirus E1A binding domain (i.e. “pocket region”) that is believed to play a primary role in the function of these proteins. A protein designated p130 shows a high degree of identity with pRb and p107 and also possesses a pocket region.
p107 (SD9) Product Citations
See how others have used p107 (SD9): sc-250 antibody and or p107 (SD9) antibody conjugates.
31 total citations
Loading citations.
p107 (SD9)
Click on image to enlarge
p107 (SD9): sc-250. Western blot analysis of p107 expression in NIH/3T3 (A) and KNRK (B) cell extracts.
p107 (SD9): sc-250. Western blot analysis of p107 expression in non-transfected: sc-117752 (A) and truncated human p107 transfected: sc-114727 (B) 293T whole cell lysates.
p107 (SD9): sc-250. Western blot analysis of p107 expression in non-transfected: sc-117752 (A) and human p107 transfected: sc-175404 (B) 293T whole cell lysates.
