TMEM231 Antibody (V-17): sc-249021

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TMEM231 (transmembrane protein 231), also known as ALYE870 or PRO1886, is a 316 amino acid multi-pass membrane protein that belongs to the TMEM231 family and is encoded by a gene that maps to human chromosome 16q23.1. Chromosome 16 encodes over 900 genes and comprises nearly 3% of human cellular DNA. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, through the CREBBP gene, which encodes a critical CREB binding protein. Crohn's disease is a gastrointestinal inflammatory condition associated with chromosome 16 through the NOD2 gene. An association with systemic lupus erythematosis and a number of other autoimmune disorders with the pericentromeric region of chromosome 16 has led to the identification of SLC5A11 as a potential autoimmune modifier.