cyclin E Background Information Cyclins were first identified in invertebrates as proteins that oscillate dramatically through the cell cycle. These proteins have been well conserved through evolution and play a critical role in regulation of cell division. cyclin E, along with the three cyclin D proteins and cyclin C, has been shown to represent a putative G1 cyclin on the basis of its cyclic pattern of mRNA expression, with maximal levels being detected near the G1/S boundary. cyclin E has been found to be associated with the transcription factor E2F in a temporally regulated manner. The cyclin E/E2F complex is detected primarily during the G1 phase of the cell cycle and decreases as cells enter S phase. E2F is known to be a critical transcription factor for expression of several S phase specific proteins.
cyclin E (HE12) Product Citations
See how others have used cyclin E (HE12): sc-247 antibody and or cyclin E (HE12) antibody conjugates.
189 total citations
Loading citations.
cyclin E (HE12)
Click on image to enlarge
cyclin E (HE12): sc-247. Western blot analysis of cyclin E expression in K-562 (A) and Jurkat (B,C) nuclear extracts.
cyclin E siRNA (h): sc-29288. Western blot analysis of cyclin E expression in non-transfected control (A) and cyclin E siRNA transfected (B) Jurkat cells. Blot probed with cyclin E (HE12): sc-247. GAPDH (FL-335): sc-25778 used as specificity and loading control.
cyclin E (HE12): sc-247. Western blot analysis of cyclin E expression in non-transfected 293T: sc-117752 (A), human cyclin E transfected 293T: sc-170464 (B) and K-562 (C) whole cell lysates.
cyclin E (HE12): sc-247. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear localization.
