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NDUFS8 Antibody (T-20): sc-243593

 |  Datasheet

(Based on data analysis)
  • NDUFS8 Antibody (T-20) is a goat polyclonal IgG provided at 200 µg/ml
  • epitope mapping within an internal region of NDUFS8 of human origin
  • recommended for detection of NDUFS8 of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
  • blocking peptide, sc-243593 P
 

See additional NDUFS Antibodies including NDUFS, NDUFS1, NDUFS2, NDUFS4, NDUFS6, NDUFS7, NDUFS5 and NDUFS8.

Ordering InformationGene Info
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 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
NDUFS8 Antibody (T-20) sc-243593 200 µg/ml $279
NDUFS8 (T-20) P sc-243593 P
(peptide)
 100 µg/0.5 ml $61
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human NDUFS8 4728 11q13.2 NM_002496 O00217
 602141
Mouse Ndufs8 225887 19 A NM_144870 Q8K3J1
 N/A
 

Located in the mitochondrial inner membrane, mitochondrial complex I is the first and largest enzyme in the electron transport chain of oxidative phosphorylation. By oxidizing NADH that is produced during the Krebs cycle, this complex utilizes two electrons to reduce ubiquinone to ubiquinol, thereby initiating the passage of electrons to successive complexes and ultimately leading to the reduction of oxygen to water. Mitochondrial complex I consists of over 40 subunits and is of considerable clinical interest since defects in any of the subunits can lead to various myopathies and neuropathies. As a subunit of mitochondrial complex I, NDUFS8 (NADH dehydrogenase [ubiquinone] iron-sulfur protein 8), also known as TYKY, CI-23k, CI23KD or NADH-ubiquinone oxidoreductase 23 kDa subunit, is a 210 amino acid protein that is suggested to be required for catalytic activity. Defects in the gene encoding NDUFS8 are the cause of Leigh syndrome, a severe neurological disorder that is characterized by bilaterally symmetrical necrotic lesions in subcortical brain regions.