SERF1 Antibody (R-14): sc-240857

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SERF1 (small EDRK-rich factor 1), also known as protein 4F5, SMAM1 (SMA modifier 1), SERF1A or SERF1B, is a 110 amino acid protein that exists as two alternatively spliced isoforms, designated isoform short and isoform long. Both SERF1 isoforms are expressed in spinal cord and central nervous system, but only isoform long is found in heart and skeletal muscle. The gene encoding SERF1 maps to human chromosome 5, which contains 181 million base pairs and comprises nearly 6% of the human genome. Chromosome 5 is associated with Cockayne syndrome through the ERCC8 gene and familial adenomatous polyposis through the adenomatous polyposis coli (APC) tumor suppressor gene. Treacher Collins syndrome is also chromosome 5-associated and is caused by insertions or deletions within the TCOF1 gene. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome, while deletion of the q arm or of chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome.