H-7, Dihydrochloride CAS (108930-17-2) sc-24009

santa cruz biotechnology, inc.

Research Products
Primary Antibodies Secondary Antibodies, Control Antibodies and Normal Sera Phospho-Specific Antibodies Flow Cytometry Antibodies for IHC (Paraffin) Staining Protein A, G PLUS and L-Agarose siRNA and shRNA (plasmid and lentivirus) Products Tissue Extracts, Cell Lysates and Proteins Transfected Cell Lysates Specialty Reagents and Buffers Veterinary Research Antibodies
Chemicals
Biochemicals Prepared Buffers Buffers and Standard Lab Chemicals Stains and Dyes Solvents HRP and AP Substrates
Lab Supplies
Lab Supplies UltraCruz™ExactaCruz™CrystalCruz™
Animal Health
Animal Health Promotionals
What's New
Promotionals Animal Health Promotionals LIF Protein Veterinary Research Antibodies Monoclonal Antibodies Polyclonal Antibodies
Company Info
Company Info Contact Us Protocols Product Citations Datasheets / MSDS Technical Service Catalog Request Chromosome DBase Cruz Credits™Investigator Awards Job Opportunities Distributors

H-7, Dihydrochloride: sc-24009	\| Datasheet \| MSDS

Specifications
- Offered as 10 mg (sc-24009) and 50 mg (sc-24009A) sizes
- Synonym: 1-(5-Isoquinolinylsulfonyl)-2-methylpiperazine dihydrochloride
- CAS Number: 108930-17-2
- Molecular Weight: 364.3
- Molecular Formula: C₁₄H₁₇N₃O₂S··2HCl
- Purity: ≥98%
- Physical Appearance: White solid
- SMILES: CC1CNCCN1S(=O)(=O)C2=CC=CC3=C2C=CN=C3.Cl.Cl
Description
- A cell-permeable, reversible, ATP-competitive Ser/Thr kinase inhibitor. H-7 is a broad spectrum kinase inhibitor that has been shown to inhibit MYLK (MLCK) (K_i=97 µM), cAMP-dependent protein kinase (PKA) (K_i = 3.0 uM), Protein Kinase C (PKC) (K_i = 6.0 uM), and cGMP-dependent protein kinase (cGKI, PKG) (K_i = 5.8 uM). H-7 inhibits cell invasion and metastasis in B16BL6 cancer cells through the PKC/MEK/ERK pathway. Shown to inhibit Topo I and II in murine L929 cells and induce apoptosis through PKC inhibition.
Storage
- Store at -20° C
For Research Use Only
Reference Numbers
- PubChem Compound ID: 73332
- MDL Number: MFCD00036961
- Beilstein Registry Number: 5840763
References
- 1. Kawamoto, S., et al. 1984. Biochem. Biophys. Res. Commun. 125: 258-264. PMID: 6239622
  2. Hidaka, H., et al. 1984. Biochemistry. 23: 5036-5041. PMID: 6238627
  3. Quick, J., et al. 1992. Biochem. Biophys. Res. Commun. 187: 657-663. PMID: 1530623
  4. Baloch, Z., et al. 1995. Cell. Immunol. 160: 98-103. PMID: 7842491
  5. Nishida, S., et al. 2003. Life Sci. 74: 781-792. PMID: 14654170
  6. Tsubaki, M., et al. 2007. Clin. Exp. Metastasis. 24: 431-438. PMID: 17636410

Set Currency

Ordering Information

Product Name	Catalog #	Unit	Price	Qty	Add	Favorites
H-7, Dihydrochloride	sc-24009	10 mg	$74
H-7, Dihydrochloride	sc-24009A	50 mg	$295

H-7, Dihydrochloride

Click on image to enlarge

Download

Datasheets

Get Adobe Acrobat Reader

H-7, Dihydrochloride: sc-24009