H2-I-A/I-E (M5/114) Antibody sc-23940

santa cruz biotechnology, inc.

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H2-I-A/I-E (M5/114) Antibody: sc-23940	\| Datasheet

rat monoclonal IgG_2b; 200 µg/ml
raised against activated C57BL/6 mouse spleen cells
recommended for detection of I-A^b, I-A^d, I-A^q, I-E^d and I-E^k MHC class II alloantigens of mouse origin by IF and FCM; non cross-reactive with I-A^f, I-A^k or I-A^s; detects a polymorphic determinant present on B cells, monocytes, macrophages, dendritic cells and activated T lymphocytes from mice carrying the H2^b, H2^d, H2^q, H2^p, H2^r and H2^u but not mice carrying the H2^s or H2^f haplotypes.
fluorescein (sc-23940 FITC) and phycoerythrin (sc-23940 PE) conjugates for FCM, 100 tests

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IF FCM

Species	Gene Name	Gene ID	Chromosome Location	Protein Accession #	OMIM™ Number

Mouse	H2-Ab1	14961	17 B1	P01921,P06342,P06343,P06344,P06345,P06346,P14483	N/A
Mouse	H2-Ab1	14961	17 B1	P01921,P06342,P06343,P06344,P06345,P06346,P14483	N/A

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Ordering Information

Product Name	Catalog #	Unit	Price
H2-I-A/I-E (M5/114)	sc-23940	200 µg/ml	$279
H2-I-A/I-E (M5/114) FITC	sc-23940 FITC	100 tests in 2 ml	$292
H2-I-A/I-E (M5/114) PE	sc-23940 PE	100 tests in 2ml	$303

H2-I-A/I-E Background Information
Major histocompatibility complex (MHC) molecules, which include human leu-kocyte antigens (HLAs), form an integral part of the immune response system. They are cell-surface receptors that bind foreign peptides and present them to cytotoxic T lymphocytes (CTLs). The differential structural properties of MHC class I and II molecules account for their respective roles in activating different populations of T lymphocytes. The M5/114 (M5/114.15.2) monoclonal antibody reacts with the mouse MHC class II, both I-A and I-E subregion-encoded glycoproteins (I-Ab, I-Ad, I-Aq, I-Ed and I-Ek; not I-Af, I-Ak or I-As). It detects a polymorphic determinant present on B cells, monocytes, macrophages, dendritic cells and activated T lymphocytes from mice carrying the H-2b, H-2d, H-2q, H-2p, H-2r and H-2u, but not from mice carrying the H-2s or H-2f haplotypes. The M5/ 114 (M5/114.15.2) mAb is reported to inhibit I-A-restricted T cell responses of the H-2b, H-2d, H-2q and H-2u, but not H-2f, H-2k or H-2s haplotypes.

H2-I-A/I-E (M5/114)

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H2-I-A/I-E (M5/114) PE: sc-23940 PE. FCM analysis of C57BL/6 mouse splenocytes. Black line histogram represents the isotype control, normal rat IgG_2b: sc-2873.

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H2-I-A/I-E (M5/114) Antibody: sc-23940