DC-SIGN Antibody (1B10): sc-23926
- DC-SIGN Antibody (1B10) is a mouse monoclonal IgG2a κ, cited in 7 publications, provided at 200 µg/ml
- recommended for detection of DC-SIGN of human origin by WB, IF, IHC(P) and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- m-IgG2a BP-HRP is the preferred secondary detection reagent for DC-SIGN Antibody (1B10) for WB and IHC(P) applications. This reagent is now offered in a bundle with DC-SIGN Antibody (1B10) (see ordering information below).
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DC-SIGN Antibody (1B10) is a mouse monoclonal IgG2a light chain antibody that detects DC-SIGN in human samples through applications such as western blotting (WB), immunofluorescence (IF), immunohistochemistry, and flow cytometry (FCM). DC-SIGN, also known as CD209, is a type II membrane protein predominantly expressed on dendritic cells, which play a crucial role in the immune response by presenting antigens to T cells. The unique structure of DC-SIGN, featuring a C-type lectin domain, allows DC-SIGN to bind specifically to various pathogens, including HIV-1, facilitating their capture and transport from mucosal surfaces to lymphoid tissues. This interaction is vital for initiating immune responses, as DC-SIGN enables dendritic cells to efficiently present viral antigens to T cells, thereby promoting adaptive immunity. The ability of DC-SIGN to mediate the initial contact between dendritic cells and resting T cells underscores DC-SIGN′s importance in the immunological synapse, making anti-DC-SIGN antibody (1B10) an essential tool for researchers studying immune responses and pathogen interactions.
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DC-SIGN Antibody (1B10) References:
- DC-SIGN (CD209) expression is IL-4 dependent and is negatively regulated by IFN, TGF-beta, and anti-inflammatory agents. | Relloso, M., et al. 2002. J Immunol. 168: 2634-43. PMID: 11884427
- DC-SIGN (CD209) mediates dengue virus infection of human dendritic cells. | Tassaneetrithep, B., et al. 2003. J Exp Med. 197: 823-9. PMID: 12682107
- L-SIGN (CD209L) and DC-SIGN (CD209) mediate transinfection of liver cells by hepatitis C virus. | Cormier, EG., et al. 2004. Proc Natl Acad Sci U S A. 101: 14067-72. PMID: 15371595
- Promoter variation in the DC-SIGN-encoding gene CD209 is associated with tuberculosis. | Barreiro, LB., et al. 2006. PLoS Med. 3: e20. PMID: 16379498
- DC-SIGN (CD209) Promoter -336 A/G polymorphism is associated with dengue hemorrhagic fever and correlated to DC-SIGN expression and immune augmentation. | Wang, L., et al. 2011. PLoS Negl Trop Dis. 5: e934. PMID: 21245921
- DC-SIGN(+) Macrophages Control the Induction of Transplantation Tolerance. | Conde, P., et al. 2015. Immunity. 42: 1143-58. PMID: 26070485
- C-type Lectin CD209L/L-SIGN and CD209/DC-SIGN: Cell Adhesion Molecules Turned to Pathogen Recognition Receptors. | Rahimi, N. 2020. Biology (Basel). 10: PMID: 33375175
- Proteus mirabilis Targets Atherosclerosis Plaques in Human Coronary Arteries via DC-SIGN (CD209). | Xue, Y., et al. 2020. Front Immunol. 11: 579010. PMID: 33488579
- CD209L/L-SIGN and CD209/DC-SIGN Act as Receptors for SARS-CoV-2. | Amraei, R., et al. 2021. ACS Cent Sci. 7: 1156-1165. PMID: 34341769
- The role of DC-SIGN as a trans-receptor in infection by MERS-CoV. | Labiod, N., et al. 2023. Front Cell Infect Microbiol. 13: 1177270. PMID: 37808906
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DC-SIGN Antibody (1B10) | sc-23926 | 200 µg/ml | $316.00 | |||
DC-SIGN Antibody (1B10): m-IgG2a BP-HRP Bundle | sc-545991 | 200 µg Ab; 10 µg BP | $354.00 | |||
DC-SIGN Antibody (1B10) FITC | sc-23926 FITC | 200 µg/ml | $330.00 | |||
DC-SIGN Antibody (1B10) PE | sc-23926 PE | 200 µg/ml | $343.00 |