Integrin β7/ITGB7 Antibody (FIB504): sc-23919
- Integrin β7/ITGB7 Antibody (FIB504) is a rat monoclonal IgG2a provided at 200 µg/ml
- raised against cells of the TK1 murine T-cell lymphoma
- Anti-Integrin β7/ITGB7 Antibody (FIB504) is recommended for detection of Integrin β7 of mouse, rat and human origin by IF and FCM
- Anti-Integrin β7/ITGB7 Antibody (FIB504) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also provided azide-free for inhibition of cell adhesion to VCAM-1, fibronectin, MadCAM-1, and intestinal epithelium, sc-23919 L, 200 µg/0.1 ml
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Integrin β7/ITGB7 Antibody (FIB504). This work is in progress.
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Integrin β7 Antibody (FIB504) is a rat monoclonal IgG2a antibody that detects Integrin β7 in mouse, rat, and human samples through immunofluorescence (IF) and flow cytometry (FCM) applications. Anti-Integrin β7 antibody (FIB504) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Integrin β7 is a crucial component of the integrin family, which consists of heterodimers formed by noncovalently associated transmembrane α and β subunits. The specific structure of Integrin β7 allows interaction with various ligands, including components of the extracellular matrix such as fibronectin and collagen, as well as counterreceptors on adjacent cells, which is vital for processes like cell adhesion and migration. Integrin β7′s ability to mediate these interactions is essential for maintaining tissue integrity and facilitating immune responses, particularly in the gut, where Integrin β7 plays a significant role in the homing of lymphocytes to mucosal tissues. Understanding Integrin β7′s function and interactions helps researchers gain insights into involvement in various physiological and pathological processes, including inflammation and cancer metastasis.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Integrin β7/ITGB7 Antibody (FIB504) References:
- Integrins: versatility, modulation, and signaling in cell adhesion. | Hynes, RO. 1992. Cell. 69: 11-25. PMID: 1555235
- Integrins and signal transduction pathways: the road taken. | Clark, EA. and Brugge, JS. 1995. Science. 268: 233-9. PMID: 7716514
- Synergistic roles for receptor occupancy and aggregation in integrin transmembrane function. | Miyamoto, S., et al. 1995. Science. 267: 883-5. PMID: 7846531
- Epithelial integrins. | Sheppard, D. 1996. Bioessays. 18: 655-60. PMID: 8760339
- Cooperation between soluble factors and integrin-mediated cell anchorage in the control of cell growth and differentiation. | Juliano, R. 1996. Bioessays. 18: 911-7. PMID: 8939069
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Integrin β7/ITGB7 Antibody (FIB504) | sc-23919 | 200 µg/ml | $322.00 | |||
Integrin β7/ITGB7 Antibody (FIB504) L | sc-23919 L | 200 µg/0.1 ml | $322.00 | |||
Integrin β7/ITGB7 Antibody (FIB504) AC | sc-23919 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Integrin β7/ITGB7 Antibody (FIB504) HRP | sc-23919 HRP | 200 µg/ml | $322.00 | |||
Integrin β7/ITGB7 Antibody (FIB504) FITC | sc-23919 FITC | 200 µg/ml | $336.00 | |||
Integrin β7/ITGB7 Antibody (FIB504) PE | sc-23919 PE | 200 µg/ml | $349.00 | |||
Integrin β7/ITGB7 Antibody (FIB504) Alexa Fluor® 488 | sc-23919 AF488 | 200 µg/ml | $364.00 | |||
Integrin β7/ITGB7 Antibody (FIB504) Alexa Fluor® 546 | sc-23919 AF546 | 200 µg/ml | $364.00 | |||
Integrin β7/ITGB7 Antibody (FIB504) Alexa Fluor® 594 | sc-23919 AF594 | 200 µg/ml | $364.00 | |||
Integrin β7/ITGB7 Antibody (FIB504) Alexa Fluor® 647 | sc-23919 AF647 | 200 µg/ml | $364.00 | |||
Integrin β7/ITGB7 Antibody (FIB504) Alexa Fluor® 680 | sc-23919 AF680 | 200 µg/ml | $364.00 | |||
Integrin β7/ITGB7 Antibody (FIB504) Alexa Fluor® 790 | sc-23919 AF790 | 200 µg/ml | $364.00 |