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- mouse monoclonal IgG1; 200 µg/ml
- raised against angiotensin-converting enzyme from human lung
- recommended for detection of ACE of mouse, rat and human origin by WB, IP, IF and IHC(P)
- agarose conjugate for IP studies, sc-23909 AC, 500 µg/0.25 ml agarose
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Ordering Information
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ACE Background Information
Angiotensin-converting enzyme (ACE) is a carboxy-terminal dipeptidyl exo-peptidase that converts Angiotensin I to the potent vasopressive hormone, Angiotensin II. There are two isoforms of ACE, the pulmonary ACEP and the testicular ACET. ACEP is a glycoprotein expressed in vascular endothelial cells of the lung, liver, adrenal cortex, pancreas, kidney and spleen. The ACET isoform is expressed exclusively in adult testis by developing sperm cells, specifically, late pachytene spermatocytes. Additionally, ACE inactivates bradykinin, a vasodepressor peptide, and is involved in fluid/electrolyte homeostasis. Although it bears significant sequence homology to ACE, ACE2 shows a more restricted pattern of expression. ACE is expressed ubiquitously throughout the vasculature while ACE2 is expressed only in cardiac, renal and testicular cells.
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ACE (5C5)
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Western blot analysis of ACE expression in human kidney tissue extract immunoprecipitated with ACE (5C5): sc-23909 and detected with ACE (N-20): sc-12184. ACE (5C5): sc-23909. Immunoperoxidase staining of formalin fixed, paraffin-embedded mouse kidney showing membrane and extracellular localization.
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