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- Armenian hamster monoclonal IgG, 200 µg/ml
- raised against ectodomain of recombinant NKG2D of mouse origin
- recommended for detection of NKG2-D of mouse origin by FCM
- also provided azide-free for stimulating the receptor, sc-23891 L, 200 µg/0.1 ml
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Ordering Information
Recommended Support Products:
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| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Mouse |
Klrk1 |
27007 |
6 F3 |
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O54709
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N/A |
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NKG2-D Background Information
The activity of natural killer (NK) cells is regulated by members of multiple receptor families that recognize class I MHC molecules, such as the killer cell inhibitory receptor/leukocyte immunoglobulin-like receptor (KIR/LIR) family and the C-type lectin superfamily. The KIR/LIR family includes p91A (also designated pp130 or PIR-B, for paired Immunoglobulin-like receptor-B) and p91B (also designated PIR-A). p91A acts as an inhibitory receptor through interactions with SHP-1, whereas p91B acts as an activating receptor. CD94, NKG2 and Ly-49 are members of the C-type lectin superfamily of type II membrane glycoproteins. CD94 forms heterodimers with NKG2 isoforms on the surface of NK cells, whereas Ly-49 isoforms form homodimers. NKG2-D, expressed on NK cells, ©∂ T cells, and CD8+ å∫ T cells, is a receptor for the stress inducible protein MICA, an antigen frequently expressed in epithelial tumors. |
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NKG2-D (A10)
Click on image to enlarge
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NKG2-D (A10): sc-23891. Indirect FCM analysis of CHO-NKG2-D cells stained with NKG2-D (A10), followed by PE-conjugated mouse anti-armenian hamster IgG: sc-3944. Black line histogram represents the isotype control, normal armenian hamster IgG: sc-3886. NKG2-D (A10): sc-23891. Indirect FCM analysis of CHO-NKG2-D cells stained with NKG2-D (A10), followed by PE-conjugated goat anti-armenian hamster IgG: sc-3733. Black line histogram represents the isotype control, normal armenian hamster IgG: sc-3886. |
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