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Qa-1 (6A8.6F10) Antibody: sc-23889 |
| Datasheet |
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- mouse monoclonal IgG1; 200 µg/ml
- raised against amino acids 161-179 of mouse Qa-1b
- recommended for detection of non classical MHC Class I (Class Ib) molecule Qa-1 of mouse origin by WB, IP, FCM, blocking of CTL function
- fluorescein (sc-23889 FITC) and phycoerythrin (sc-23889 PE) conjugates for FCM, 100 tests
- azide-free for blocks CTL function, sc-23889 L, 200 µg/0.1 ml
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Ordering Information
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| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Mouse |
H2-T23 |
15040 |
17 B1 |
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P06339
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N/A |
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Qa-1 Background Information
Major histocompatibility complex (MHC) molecules, which include human leukocyte antigens (HLAs), are cell-surface receptors that bind foreign peptides and present them to cytotoxic T lymphocytes (CTLs). MHC class I molecules consist of two polypeptide chains, an a or heavy chain, and a non-covalently associated protein, b2-microglobulin. Antigens that bind to MHC class I molecules are typically 8-10 residues in length, and are stabilized in a peptide binding groove. Qa-1, a murine MHC class Ib molecule, presents the Qa-1 determinant modifier (Qdm) peptide to the CD94/NKG2A receptor on natural killer (NK) cells. This interaction participates in protecting self cells by inhibiting NK cytotoxicity, and may be mediated by CD8, since the Qa-1 protein preferentially binds to CD8 (+), but not CD4 (+), T cells. The gene encoding murine Qa-1 maps to chromosome 17. |
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Qa-1 (6A8.6F10)
Click on image to enlarge
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Qa-1 (6A8.6F10): sc-23889. Western blot analysis of Qa-1 expression in mouse thymus tissue extract.
Qa-1 (6A8.6F10): sc-23889. Western blot analysis of Qa-1 expression in WEHI-3 (A) and TK-1 (B) whole cell lysates.
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