epitope mapping within an extracellular domain of APLP2 of human origin
recommended for detection of APLP2 of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
APLP2 Background Information APLP1 (amyloid precursor-like protein 1) is a protein whose predicted amino acid sequence is 42% identical and 64% similar to that of the amyloid beta protein precursor (APP). This 653-amino acid protein is also similar to APP in overall structure. The gene which encodes APLP1 maps to human chromosome 19cen-q13.2. Since congenital nephrotic syndrome (CNF) maps close to APLP1, and because of the proposed interference of amyloid with basement membrane assembly, APLP1 had incorrectly been considered a candidate gene for CNF. APLP2 is a human sperm membrane protein which contains a segment with high homology to the transmembrane-cytoplasmic domains of APP found in brain plaques of Alzheimer disease patients. The human amyloid precursor-like protein APLP2 is a highly conserved homolog of a sequence-specific DNA-binding mouse protein with an important function in the cell cycle. The gene which encodes APLP2 maps to human chromosome 11q24.
