epitope mapping within an internal region of NKIAMRE of human origin
recommended for detection of NKIAMRE of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including equine, canine and bovine
NKIAMRE Background Information The cell division cycle is regulated by a closely-related family of protein kinases known as cyclin-dependent kinases, or CDKs. CDK family members share high levels of sequence homology between species, suggesting that evolutionarily conserved mechanisms of cell cycle control may exist. NKIAMRE, also designated cyclin-dependent kinase-like 3, is a member of the CDK family. The human NKIAMRE gene maps to chromosome 5q31.1 and encodes a 455 amino acid protein, which is believed to be a tumor suppressor. The NKIAMRE gene was identified as a gene absent in human acute leukemia and myelodysplasia patients with interstitial deletions in chromosome arm 5q. This deleted region may contain tumor suppressor loci that are necessary for normal hematopoiesis. NKIAMRE shares close homology to the cdc2-related kinases NKIATRE, KKIALRE, PISSLRE, PITALRE and KKIAMRE, containing both conserved inhibitory phosphorylation sites and a putative cyclin-binding domain. These kinases influence cell behavior through restricting cell growth or maintaining differentiation.
