epitope mapping within an internal region of Hrs of human origin
recommended for detection of Hrs of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including canine, bovine and avian
Hrs Background Information The hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) is a zinc-finger protein that interacts with STAM and undergoes tyrosine phosphorylation in response to IL2, CSF2 or HGF. Hrs is involved in intracellular trafficking and signal transduction and is associated with early endosomes.
Hrs contains a phosphatidylinositol 3-phosphate-binding domain that contributes to its endosomal targeting, where Hrs co-localizes with Clathrin via a Clathrin box motif at the carboxy-terminus of Hrs. Hrs is essential for ventral folding morphogenesis and shares structual similarity to the yeast protein Vps27p, which is involved in vacuolar protein sorting. The human Hrs gene, which maps to chromosome 17q25, enodes a 777 amino acid protein. In Schwann cells, Hrs co-localizes at endosomes with the tumor suppressor protein schwannomin, suggesting a role for schwannomin in Hrs-mediated cell signaling.
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Hrs (V-20)
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Hrs (V-20): sc-23791. Western blot analysis of Hrs expression in CCRF-CEM (A), AML-193 (B) and HEL 92.1.7 (C) whole cell lysates.
Hrs (V-20): sc-23791. Western blot analysis of Hrs expression in non-transfected: sc-117752 (A) and mouse Hrs transfected: sc-125474 (B) 293T whole cell lysates.
