p-survivin (Thr 34)-R Antibody: sc-23758-R

survivin Background Information
Two mammalian homologs of baculovirus p35, referred to as inhibitor of apoptosis protein (IAP) 1 and 2, share an amino terminal baculovirus IAP repeat (BIR) motif and a carboxy terminal ring finger. Although the c-IAPs do not directly associate with the TNF receptor (TNF-R), they efficiently block TNF-mediated apoptosis through their interaction with the downstream TNF-R effectors, TRAF1 and TRAF2. Additional IAP family members include, ILP (for IAP-like protein) and survivin. ILP inhibits activated caspase-3, leading to the resistance of FAS-mediated apoptosis. Whereas an increase in caspase-3 activity occurs when the survivin-microtubule interaction is disrupted, survivin (also designated TIAP) is expressed during the G2/M phase of the cell cycle and associates with microtubules of the mitotic spindle. Cyclin-dependent kinase p34cdc2 associates with survivin and phosphorylates survivin at Thr 34 in vivo . Loss of phosphorylation at Thr 34 leads to dissociation of the survivin-caspase-9-complex on the mitotic apparatus.