HMGI-C (S-15) Antibody: sc-23684

HMGI-C Background Information
High mobility group (HMG) proteins 1 and 2 are ubiquitous non-histone components of chromatin. The binding of HMG proteins to the minor groove of AT-rich DNA sequences induces alterations in the DNA architecture, including DNA bending and unwinding of the helix. While HMG proteins do not stimulate initiation of transcription, they do enhance the binding of other transcription factors, such as Oct-2, members of the NFkB family, ATF-2 and c-Jun, to activate transcription. Human HMG-1 and HMG-2 contain two DNA-binding domains, termed HMG boxes. HMG proteins bind single-stranded and double-stranded DNA, but only induce conformational changes in double-stranded DNA. The gene encoding human HMGI-C, another HMG family member, maps to chromosome 12q15. Chromosomal translocations of the HMGI-C gene frequently appear in tumors of mesenchymal origin. Truncation of the HMGI-C gene leads to abnormal HMGI-C expression and transformation. Transgenic mice with HMGI-C truncation develop natural killer cell lymphomas and exhibit a giant phenotype.