Date published: 2025-9-10

1-800-457-3801

SCBT Portrait Logo
Seach Input

N6-Methyladenine (CAS 443-72-1)

5.0(1)
Write a reviewAsk a question

See product citations (1)

Alternate Names:
6-(Methylamino)purine
Application:
N6-Methyladenine is a useful purine for proteomics research
CAS Number:
443-72-1
Purity:
≥95%
Molecular Weight:
149.15
Molecular Formula:
C6H7N5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

N6-Methyladenine (6MA) is a highly significant organic compound with diverse applications in scientific research. It is derived from adenine, a nucleobase found in both DNA and RNA. The versatility of N6-Methyladenine lies in its ability to function as a substrate, inhibitor, and activator of various enzymes and proteins, making it invaluable in biochemical and physiological studies. As a substrate, N6-Methyladenine serves as useful to investigate the impact of specific drugs on cellular processes. Its role as an inhibitor allows researchers to explore DNA damage, repair mechanisms, and gene expression. Furthermore, as an activator, N6-Methyladenine contributes to the understanding of gene silencing and activation, shedding light on important regulatory processes within cells.


N6-Methyladenine (CAS 443-72-1) References

  1. N6-methyladenine DNA modification in Drosophila.  |  Zhang, G., et al. 2015. Cell. 161: 893-906. PMID: 25936838
  2. N6-methyladenine functions as a potential epigenetic mark in eukaryotes.  |  Sun, Q., et al. 2015. Bioessays. 37: 1155-62. PMID: 26293475
  3. N6-methyladenine RNA modification and cancers.  |  Wu, X., et al. 2018. Am J Cancer Res. 8: 1957-1966. PMID: 30416848
  4. DNA N6-methyladenine increased in human esophageal squamous cell carcinoma.  |  Chen, L., et al. 2020. Discov Med. 29: 85-90. PMID: 33002404
  5. N6-methyladenine and epigenetic immunity of Deinococcus radiodurans.  |  Joshi, S., et al. 2021. Res Microbiol. 172: 103789. PMID: 33188877
  6. N6-methyladenine-related genes affect biological behavior and the prognosis of glioma.  |  Qu, S., et al. 2021. Cancer Med. 10: 98-108. PMID: 33264518
  7. N6-methyladenine modification in noncoding RNAs and its function in cancer.  |  Yang, X., et al. 2020. Biomark Res. 8: 61. PMID: 33292652
  8. ALKBH1-demethylated DNA N6-methyladenine modification triggers vascular calcification via osteogenic reprogramming in chronic kidney disease.  |  Ouyang, L., et al. 2021. J Clin Invest. 131: PMID: 34003800
  9. N6-methyladenosine reader IMP2 stabilizes the ZFAS1/OLA1 axis and activates the Warburg effect: implication in colorectal cancer.  |  Lu, S., et al. 2021. J Hematol Oncol. 14: 188. PMID: 34743750
  10. Alkbh1-mediated DNA N6-methyladenine modification regulates bone marrow mesenchymal stem cell fate during skeletal aging.  |  Cai, GP., et al. 2022. Cell Prolif. 55: e13178. PMID: 35018683
  11. DNA N6-methyladenine involvement and regulation of hepatocellular carcinoma development.  |  Lin, Q., et al. 2022. Genomics. 114: 110265. PMID: 35032618
  12. N6-methyladenine-modified DNA was decreased in Alzheimer's disease patients.  |  Lv, S., et al. 2022. World J Clin Cases. 10: 448-457. PMID: 35097069
  13. BERT6mA: prediction of DNA N6-methyladenine site using deep learning-based approaches.  |  Tsukiyama, S., et al. 2022. Brief Bioinform. 23: PMID: 35225328
  14. Transcriptome-wide N6-methyladenine methylation in granulosa cells of women with decreased ovarian reserve.  |  Liu, C., et al. 2022. BMC Genomics. 23: 240. PMID: 35346019
  15. N6-methyladenine- induced LINC00667 promoted breast cancer progression through m6A/KIAA1429 positive feedback loop.  |  Ren, S., et al. 2022. Bioengineered. 13: 13462-13473. PMID: 36700472

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

N6-Methyladenine, 250 mg

sc-236150
250 mg
$178.00