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Calpain 3 Antibody (N-17): sc-23500

 |  Datasheet

(Based on data analysis)

  • Calpain 3 Antibody (N-17) is a goat polyclonal IgG provided at 200 µg/ml
  • epitope mapping near the N-terminus of Calpain 3 of human origin
  • recommended for detection of Calpain 3 of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
  • blocking peptide, sc-23500 P
 

See additional Calpain Antibodies including Calpain, Calpain 1, Calpain reg, Calpain 2, Calpain 3, Calpain 5, Calpain 6, Calpain 7, Calpain 8, Calpain 9, Calpain 10, Calpain 11, Calpain 12, Calpain 13 and Calpain 15.

Also see Calpain Inhibitors for functional analysis of cellular responses to Calpain.


Ordering InformationGene Info
Recommended Support Products:
(click button of application of choice)
WB   IF   siRNA  
Set Currency

 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
Calpain 3 Antibody (N-17) sc-23500 200 µg/ml $279
Calpain 3 (N-17) P sc-23500 P
(peptide)
100 µg/0.5 ml $61
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Calpain 3 siRNA (h) sc-41461 10 µM $258
Calpain 3 siRNA (m) sc-41462 10 µM $258
Calpain 3 (h)-PR sc-41461-PR 10 µM, 20 µl $23
Calpain 3 (m)-PR sc-41462-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Calpain 3 shRNA Plasmid (h) sc-41461-SH 20 µg $520
Calpain 3 shRNA Plasmid (m) sc-41462-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Calpain 3 shRNA (h) Lentiviral Particles sc-41461-V 200 µl $625
Calpain 3 shRNA (m) Lentiviral Particles sc-41462-V 200 µl $625
 WB Positive Control Cell Lysate (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
mouse brain extract sc-2253 500 µg/200 µl $104
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human CAPN3 825 15q15.1 NM_000070, NM_024344, NM_173087, NM_173088, NM_173089, NM_173090, NM_212464, NM_212465, NM_212467 P20807
253600
Mouse Capn3 12335 2 E5 Q64691
N/A
 


Calpain, an intracellular calcium-dependent protease that cleaves cytoskeletal and submembranous proteins, plays a role in cytoskeletal reorganization and muscle protein degradation (1). Calpain is a heterodimer composed of a small regulatory subunit and one of three large catalytic subunits, designated calpain 1, calpain 2 and calpain 3 (2). Calpain 3 (calpain p94) is a muscle-preferred calcium activated neutral protease that localizes to the nucleus (3). The gene encoding human calpain 3 maps to chromosome 15q15.1-q21.1 (4). Mutations involving the calpain 3 gene are associated with limb-girdle muscle dystrophy type 2A, a form of autosomal recessive and progressive neuromuscular disorder (4). Calpastatin regulates calpain by inhibiting both the proteolytic activity of calpain and its binding to membranes (5,6). Calpastatin exists in two types, tissue type and erythrocyte type, resulting from both alternative splicing and proteolytic processing (7,8).