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Betulin (CAS 473-98-3)

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Synonym:Lup-20(29)-ene-3β,28-diol
Application:A triterpene with a pentacyclic ring structure
CAS Number:473-98-3
Molecular Weight:442.72
Molecular Formula:C30H50O2
Refer to Certificate of Analysis for lot specific data (including water content).
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Product NameCatalog #UnitPriceQtyAddFavorites
Betulin sc-234016 1 g $129
Description
Betulin is a triterpene with a pentacyclic ring structure and hydroxyl groups in positions C3 and C28. Studies indicate that Betulin can effect intracellular signaling in ethanol-induced liver cells via inhibiting ROS, TNFα and TNFβ. In human cancer cells Betulin can induce mitochondrial cytochrome C release in human cancer cells, which results in apoptosis. Alternate studies on mice show that Betulin binds to melanocortin receptors and antagonizes the release of cAMP generation in mouse melanoma cells. Furthermore, Betulin has protective effects against cadmium induced apoptosis in human hepatoma cell lines. This occurs by inhibiting the activation of ROS, blocking Bid activation and suppressing the mitochondrial pathway.
Technical Information
Physical State:Solid
Storage:Store at 4° C
Safety and Reference Information
PubChem CID:72326
SMILES:CC(=C)[C@@H]1CC[C@]2(CO)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[ C@@H]5CC[C@@]34C)[C@@H]12
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
References
1. Oh, S.H., et al. 2006. Toxicology. 220: 1-12. PMID: 16436312
2. Muceniece, R., et al. 2007. Cell Biochem. Funct. 25: 591-596. PMID: 17605140
3. Li, Y., et al. 2010. Mol. Carcinog. 49: 630-640. PMID: 20564340
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