CARP (T-15) Antibody: sc-23251

CARP Background Information
A proposed genetic marker of cardiac hypertrophy, CARP (cardiac ankyrin repeat protein) is a nuclear protein with an established role in regulation of cardiac gene expression (1,2). A distinct increase in CARP expression occurs in rats with abdominal aorta constriction, spontaneous hypertension and Dahl salt-sensitivity (1). In cardiomyocytes, CARP inhibits transcription of both cardiac troponin C and atrial natriuretic factor (3). Specifically, expression of the CARP gene, which lies downstream of the cardiac homeobox gene Nkx2.5, inhibits Nkx2.5 transactivation of atrial natriuretic factor promoter (4,3). An increase in CARP expression is observed in the ventricular tissue of patients with end-stage heart failure (5). The major Ca2+ binding protein of cardiac sarcoplasmic reticulum (SR), Calsequestrin (CSQ), upregulates the CARP gene, and may contribute to the development of cardiac hypertrophy and fibrosis (6). TGF∫ induces CARP expression in vascular smooth muscle cells (VSMCs), wherein CARP may mediate the inhibitory effects of TGF∫ on VSMC proliferation (7).