Molecular structure of 21-Hydroxyprogesterone, CAS Number: 64-85-7
21-Hydroxyprogesterone (CAS 64-85-7)
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Alternate Names:
Desoxycorticosterone
Application:
21-Hydroxyprogesterone is a mineralocorticoid
CAS Number:
64-85-7
Molecular Weight:
330.46
Molecular Formula:
C21H30O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
21-Hydroxyprogesterone is a mineralocorticoid that occurs in adrenal cortex. It acts as a precursor to Aldosterone. 21-Hydroxyprogesterone is involved in the steroidogenesis pathway. These are steroids carrying a hydroxyl group at the 21-position of the steroid backbone. Thus, 21-Hydroxyprogesterone is considered to be a steroid lipid molecule.
21-Hydroxyprogesterone (CAS 64-85-7) References
- Cytochrome P450 3A9 catalyzes the metabolism of progesterone and other steroid hormones. | Wang, H., et al. 2000. Mol Cell Biochem. 213: 127-35. PMID: 11129951
- Determination of 3-keto-4-ene steroids and their hydroxylated metabolites catalyzed by recombinant human cytochrome P450 1B1 enzyme using gas chromatography-mass spectrometry with trimethylsilyl derivatization. | Song, J., et al. 2003. J Chromatogr B Analyt Technol Biomed Life Sci. 791: 127-35. PMID: 12798173
- Bifunctional gonadotropin-releasing hormone antagonist-progesterone analogs with increased efficacy and duration of action. | Ratcliffe, KE., et al. 2006. Endocrinology. 147: 571-9. PMID: 16223868
- The glucuronidation of Delta4-3-Keto C19- and C21-hydroxysteroids by human liver microsomal and recombinant UDP-glucuronosyltransferases (UGTs): 6alpha- and 21-hydroxyprogesterone are selective substrates for UGT2B7. | Bowalgaha, K., et al. 2007. Drug Metab Dispos. 35: 363-70. PMID: 17151189
- Real-time analysis of gene regulation by glucocorticoid hormones. | McMaster, A., et al. 2008. J Endocrinol. 197: 205-11. PMID: 18434350
- A hypervariable region of P450IIC5 confers progesterone 21-hydroxylase activity to P450IIC1. | Kronbach, T., et al. 1991. Biochemistry. 30: 6097-102. PMID: 2059619
- A sensitive and rapid mass spectrometric method for the simultaneous measurement of eight steroid hormones and CALIPER pediatric reference intervals. | Kyriakopoulou, L., et al. 2013. Clin Biochem. 46: 642-51. PMID: 23337690
- Progesterone hydroxylation by cytochromes P450 2C and 3A enzymes in marmoset liver microsomes. | Nakanishi, K., et al. 2018. Xenobiotica. 48: 757-763. PMID: 28762864
- Biotransformation of Progesterone by the Ascomycete Aspergillus niger N402. | Savinova, OS., et al. 2018. Biochemistry (Mosc). 83: 26-31. PMID: 29534665
- Simultaneous solubilization of steroid hormones I: estrogens and C21 steroids. | Lövgren, T., et al. 1978. J Pharm Sci. 67: 1419-22. PMID: 702293
- Identification of progesterone binding sites in the plasma membrane of the filamentous fungus Cochliobolus lunatus. | Plemenitas, A., et al. 1993. J Steroid Biochem Mol Biol. 45: 281-5. PMID: 8499335
- The carboalkoxyallylsilane terminator for biomimetic polyene cyclizations. A route to 21-hydroxyprogesterone types | William S. Johnson, Clive Newton, Stephen D. Lindell. 1986. Tetrahedron Letters. 27: 6027-6030.
- Biotransformation of progesterone by the green alga Chlorella emersonii C211-8h | Marina Della Greca ‡, Antonio Fiorentino ‡, Gabriele Pinto ∗, Antonino Pollio ∗, Lucio Previtera ‡. 1996. Phytochemistry. 41: 1527-1529.
- Studies on Geobacillus stearothermophilus-Part V1: Transformation of 17α-hydroxyprogesterone and 21-hydroxyprogesterone | Sameera Al-Awadi, Mohammed Afzal & Sosamma Oommen. 2006. Biocatalysis and Biotransformation. 25: 43-50.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
21-Hydroxyprogesterone, 500 mg | sc-231274 | 500 mg | $235.00 | |||
21-Hydroxyprogesterone, 1 g | sc-231274A | 1 g | $397.00 |