PIMT (P-12) Antibody: sc-23114

PIMT Background Information
The PIMT (PRIP-interacting protein with methyltransferase domain) protein binds to the nuclear receptor coactivator PRIP (peroxisome proliferator-activated receptor (PPAR)-interacting protein), enhancing the coactivator function of PRIP. PIMT and PRIP co-localize to the nucleus. PPARg-induced transcription increases irrespective of singular or co-transfection of PIMT and PRIP. PIMT enhances the PBP-mediated transcriptional activity of PPARg and represses the CBP/p300-mediated transactivation of PPARg. PIMT also binds and co-localizes to the nucleus with the transcription activators CBP, p300 and PBP. PIMT may also be a putative RNA methyltransferase, as it binds both the methyl donor for the methyltransfer reaction (S-adenosyl-l-methionine) and RNA. The human PIMT gene maps to chromosome 8q11 and encodes a 852 amino acid protein, which is highly expressed in heart, skeletal muscle, kidney, liver and placenta. The PPARa-interacting cofactor (PRIC) complex comprises PIMT, PRIP, CBP, PBP and more than 20 other coactivators or coactivator-binding proteins. Ciprofibrate and leukotriene B4 both induce PRIC complex-PPARa interaction, which enhances transcription.