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- goat polyclonal IgG, 200 µg/ml
- epitope mapping within an internal region of POP5 of human origin
- recommended for detection of POP5 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
- blocking peptide, sc-23046 P
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Ordering Information
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POP5 Background Information
Ribonuclease P (PNase P) and Ribonuclease MRP (RNase MRP) are small nuclear ribonucleoproteins (snRNPs) that act on RNA substrates in vitro. RNase P and RNase MRP, which accumulate in the nucleolus, have a similar RNA component and also have several protein subunits in common. RNase P, which consists of a complex of an RNA species (H1 RNA), POP1 (Processing of Precursor 1), POP5 (Processing of Precursor 5), and at least 7 Rpps (including Rpp14, Rpp29, Rpp30 and Rpp38), removes the 5-prime leader sequences from precursor tRNA molecules. In particular, the nucleolar-localizing RNase P catalyzes the hydrolysis of a specific phosphodiester bond in precursor tRNA to form the mature 5’ end of tRNA. The structurally related RNase MRP plays an essential role in the formation of the 5’ end of 5.8S rRNA. Both RNase P and RNase MRP are associated with Th/To ribonucleoproteins; Rpp30 and Rpp38 have specifically been implicated as Th autoantigens which contribute to the autoimmune disease systemic sclerosis. |
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POP5 (P-14)
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POP5 (P-14): sc-23046. Western blot analysis of POP5 expression in mouse brain tissue extract.
POP5 (P-14): sc-23046. Western blot analysis of POP5 expression in mouse brain tissue extract.
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