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c-Abl Antibody (24-11): sc-23

 |  Datasheet

(Based on data analysis)

  • c-Abl Antibody (24-11) is a mouse monoclonal IgG1 provided at 100 µg/ml
  • raised against a region within the c-Abl C-terminus domain
  • recommended for detection of c-Abl and chimeric Bcr/Abl proteins in CML and ALL of mouse, rat and human origin by WB, IP, IF and ELISA
  • does not inhibit c-Abl tyrosine kinase activity
  • See 62 citations for c-Abl Antibody (24-11)
 

See additional c-Abl Antibodies.

Also see c-Abl Inhibitors for functional analysis of cellular responses to c-Abl.


Ordering InformationProduct CitationsGene Info
Recommended Support Products:
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WB   IP   IF   siRNA  
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
c-Abl Antibody (24-11) sc-23 100 µg/ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
c-Abl siRNA (h) sc-29843 10 µM $258
c-Abl siRNA (m) sc-29844 10 µM $258
c-Abl siRNA (h2) sc-44290 10 µM $258
c-Abl siRNA (r) sc-270357 10 µM $258
c-Abl (h)-PR sc-29843-PR 10 µM, 20 µl $23
c-Abl (m)-PR sc-29844-PR 10 µM, 20 µl $23
c-Abl (h2)-PR sc-44290-PR 10 µM, 20 µl $23
c-Abl (r)-PR sc-270357-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
c-Abl shRNA Plasmid (h) sc-29843-SH 20 µg $520
c-Abl shRNA Plasmid (m) sc-29844-SH 20 µg $520
c-Abl shRNA Plasmid (h2) sc-44290-SH 20 µg $520
c-Abl shRNA Plasmid (r) sc-270357-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
c-Abl shRNA (h) Lentiviral Particles sc-29843-V 200 µl $625
c-Abl shRNA (m) Lentiviral Particles sc-29844-V 200 µl $625
c-Abl shRNA (h2) Lentiviral Particles sc-44290-V 200 µl $625
c-Abl shRNA (r) Lentiviral Particles sc-270357-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
K-562 Whole Cell Lysate sc-2203 500 µg/200 µl $104
RAW 264.7 Whole Cell Lysate sc-2211 500 µg/200 µl $104
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Mouse Abl1 11350 2 B P00520
N/A
 


The Abl oncogene was initially identified as the viral transforming gene of Abelson murine leukemia virus (A-MuLV). The major translational product of c-Abl has been identified as a protein with tyrosine kinase activity and an SH2 domain. The Abl oncogene is implicated in several human leukemias including 90-95% of chronic myelocytic leukemia (CML), 20-25% of adult acute lymphoblastic leukemia (ALL) and 2-5% of pediatric ALL. In these leukemias the c-Abl proto-oncogene undergoes a (9;22) chromosomal translocation producing the Philadelphia (Ph1) chromosome. The molecular consequence of this trans-location is the generation of a chimeric Bcr/c-Abl mRNA encoding activated Abl protein-tyrosine kinase. The Bcr gene has been shown to encode a GTPase-activating protein (GAP) specific for the Ras-related GTP-binding protein, p21rac.

c-Abl Antibody (24-11) Product Citations
See how others have used c-Abl Antibody (24-11) and or c-Abl Antibody (24-11) conjugates.


62 total citations
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c-Abl Antibody (24-11) Data
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c-Abl (24-11): sc-23. Western blot analysis of c-Abl expression in K-562 (A) and RAW 264.7 (B) whole cell lysates.
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