Date published: 2025-9-26

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Hamamelitannin (CAS 469-32-9)

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Alternate Names:
2-C-(Hydroxymethyl)-D-ribofuranose 2′,5-digallate; Hamamelofuranose 2′,5-digallate
CAS Number:
469-32-9
Purity:
≥98%
Molecular Weight:
484.36
Molecular Formula:
C20H20O14
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Hamamelitannin is a condensed tannin found in the bark and leaves of the witch hazel plant, also known as Hamamelis virginiana. This yellowish-brown powder dissolves in water and has a bitter flavor. It earns its classification as a condensed tannin because it can create polymers via intermolecular bonds. Often used as a benchmark for identifying and measuring tannins in assorted plant extracts, Hamamelitannin also serves as an antioxidant and antimicrobial ingredient in a range of functional foods and beauty products.


Hamamelitannin (CAS 469-32-9) References

  1. Molecular process of glucose uptake and glycogen storage due to hamamelitannin via insulin signalling cascade in glucose metabolism.  |  Issac, PK., et al. 2020. Mol Biol Rep. 47: 6727-6740. PMID: 32809102
  2. Synergism of the Combination of Traditional Antibiotics and Novel Phenolic Compounds against Escherichia coli.  |  Hossain, MA., et al. 2020. Pathogens. 9: PMID: 33023003
  3. Drug Screening of Potential Multiple Target Inhibitors for Estrogen Receptor-α-positive Breast Cancer.  |  Dai, YH., et al. 2021. In Vivo. 35: 761-777. PMID: 33622869
  4. Combination Therapies for Biofilm Inhibition and Eradication: A Comparative Review of Laboratory and Preclinical Studies.  |  Hawas, S., et al. 2022. Front Cell Infect Microbiol. 12: 850030. PMID: 35281447
  5. The Effect of Tannin-Rich Witch Hazel on Growth of Probiotic Lactobacillus plantarum.  |  Rasooly, R., et al. 2022. Antibiotics (Basel). 11: PMID: 35326857
  6. Targeting SARS-CoV-2 non-structural protein 13 via helicase-inhibitor-repurposing and non-structural protein 16 through pharmacophore-based screening.  |  Samdani, MN., et al. 2023. Mol Divers. 27: 1067-1085. PMID: 35690957
  7. Bioactivity of hamamelitannin, flavokawain A, and triacetyl resveratrol as natural compounds: Molecular docking study, anticolon cancer, and anti-Alzheimer potentials.  |  Zhang, M., et al. 2022. Biotechnol Appl Biochem.. PMID: 35933706
  8. Methicillin-resistant Staphylococcus aureus as a cause of chronic wound infections: Alternative strategies for management.  |  Simonetti, O., et al. 2022. AIMS Microbiol. 8: 125-137. PMID: 35974994
  9. Unveiling the Ability of Witch Hazel (Hamamelis virginiana L.) Bark Extract to Impair Keratinocyte Inflammatory Cascade Typical of Atopic Eczema.  |  Piazza, S., et al. 2022. Int J Mol Sci. 23: PMID: 36012541
  10. Metabolomic fingerprint of Hamamelis virginiana L. gallotannins by suspect screening analysis with UHPLC-qToF and their semiquantitative evaluation.  |  Burico, M., et al. 2022. J Mass Spectrom. 57: e4878. PMID: 36065819
  11. Recent advances on the regulation of bacterial biofilm formation by herbal medicines.  |  Zhang, M., et al. 2022. Front Microbiol. 13: 1039297. PMID: 36425031
  12. From Hamamelitannin Synthesis to the Study of Enzymatic Acylations of D-Hamamelose.  |  Mastihubová, M. and Mastihuba, V. 2023. Biomolecules. 13: PMID: 36979454
  13. Ginnalin A and hamamelitannin: the unique gallotannins with promising anti-carcinogenic potential.  |  Rippin, ., et al. 2023. Explor Target Antitumor Ther. 4: 208-216. PMID: 37205316

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Hamamelitannin, 5 mg

sc-228270
5 mg
$85.00