epitope corresponding to amino acids 31-310 mapping at the N-terminus of ATF-6α of human origin
recommended for detection of ATF-6α of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine and canine
TransCruz reagent for Gel Supershift and ChIP applications, sc-22799 X, 200 µg/0.1 ml
agarose conjugate for IP studies, sc-22799 AC, 500 µg/0.25 ml agarose
ATF-6α Background Information ATF-6 is a member of the basic-leucine zipper family of transcription factors. Endoplasmic reticulum stress causes cleavage of transmembrane ATF-6 and transclocation of active ATF-6 to the nucleus. Soluble ATF-6 can exist as either an ATF-6∫ homodimer or an ATF-6å/∫ heterodimer. Binding of the ATF-6∫ homodimer or ATF-6å/∫ heterodimer to the nuclear transcription factor Y C (NF-YC) induces ER chaperone transcription.
ATF-6α (H-280) Product Citations
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ATF-6α (H-280)
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ATF-6α (H-280): sc-22799. Western blot analysis of ATF-6α expression in MCF7 nuclear extract.