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- rabbit polyclonal IgG, 200 µg/ml
- epitope corresponding to amino acids 1-90 mapping at the N-terminus of ATF-3 of human origin
- recommended for detection of ATF-3 of mouse, rat and human origin by WB, IP, IF and ELISA
- TransCruz reagent for Gel Supershift and ChIP applications, sc-22798 X, 200 µg/0.1 ml
- agarose conjugate for IP studies, sc-22798 AC, 500 µg/0.25 ml agarose
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ATF-3 Background Information
Eukaryotic gene transcription is regulated by sequence-specific transcription factors which bind modular cis acting promotor and enhancer elements. The cAMP response element (CRE), one of the best studied of such elements, consists of the palindromic octanucleotide TGACGTCA (1,2). Several CRE binding proteins have been identified within the ATF/CREB family, the best characterized of which include CREB-1, CREB-2 (also designated ATF-4), ATF-1, ATF-2 and ATF-3 (3–7). These proteins share highly related COOH terminal leucine zipper dimerization and basic DNA binding domains but are highly divergent in their amino terminal domains (5). Although each of the ATF/CREB proteins appear capable of binding CRE in its homodimeric form, certain of these also bind as heterodimers, both within the ATF/CREB family and even with members of the AP-1 transcription factor family (7).
| ATF-3 (H-90) Product Citations |
See how others have used ATF-3 (H-90): sc-22798 antibody and or ATF-3 (H-90) antibody conjugates.
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ATF-3 (H-90)
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ATF-3 (H-90): sc-22798. Western blot analysis of ATF-3 expression in RAW 264.7 (A) and PMA treated RAW 264.7 (B) whole cell lysates.
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