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home » Cell Cycle Proteins » CENP Antibody / CENP Antibodies » CENP-H (FL-247): sc-22792

CENP-H (FL-247) Antibody: sc-22792

  |  Datasheet
  • rabbit polyclonal IgG, 200 µg/ml
  • epitope corresponding to amino acids 1-247 representing full length CENP-H of human origin
  • recommended for detection of CENP-H of mouse, rat and human origin by WB, IP, IF and ELISA
 
Additional CENP Antibodies ...
 
Ordering Information
Recommended Support Products:
(click button of application of choice)
WB   IP   IF   siRNA  
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human CENPH 64946 5q13.2 NM_022909 Q9H3R5
 605607
Mouse Cenph 26886 13 D1 Q9QYM8
 N/A
 
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
CENP-H (FL-247) sc-22792 200 µg/ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
CENP-H siRNA (h) sc-37565 10 µM $258
CENP-H siRNA (m) sc-37566 10 µM $258
CENP-H (h)-PR sc-37565-PR 10 µM $23
CENP-H (m)-PR sc-37566-PR 10 µM $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
CENP-H shRNA Plasmid (h) sc-37565-SH 20 µg $520
CENP-H shRNA Plasmid (m) sc-37566-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
CENP-H shRNA (h) Lentiviral Particles sc-37565-V 200 µl $625
CENP-H shRNA (m) Lentiviral Particles sc-37566-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
HeLa Whole Cell Lysate sc-2200 500 µg/200 µl $104
HeLa nuclear extract sc-2120 1000 µg $143
NIH/3T3 nuclear extract sc-2138 1000 µg $143
Jurkat nuclear extract sc-2132 1000 µg $143
Jurkat Whole Cell Lysate sc-2204 500 µg/200 µl $104
rat testis extract sc-2400 500 µg/200 µl $104
CENP-H (h2): 293T Lysate sc-113785 100µg/200µl $205

CENP-H Background Information
A replicated chromosome includes two kinetochores that control chromosome segregation during mitosis. Both centromere proteins CENP-B and CENP-H are contained in the centromeric heterochromatin between kinetochores, and are involved in maintaining sister chromatid cohesion. The highly dispersed CENP-B promotes and maintaines the joining of DNA satellites in the centromere. CENP-B targets centromeric a-DNA and protects it from digestion by nucleases as well as preventing DNAse or restriction enzyme digestion from affecting the morphology of centromeres. CENP-H contains a coiled-coil structure and a nuclear localization signal. CENP-H is specifically and constitutively localized to kinetochores and plays a role in the organization and function of kinetochores throughout the cell cycle.

CENP-H (FL-247)
Click on image to enlarge
sc-22792
CENP-H (FL-247): sc-22792. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear localization.
sc-22792
CENP-H (FL-247): sc-22792. Western blot analysis of CENP-H expression in HeLa (A), NIH/3T3 (B) and Jurkat (C) nuclear extracts, HeLa whole cell lysate (D) and rat testis (E) and mouse embryo (F) tissue extracts.
sc-22792
CENP-H (FL-247): sc-22792. Western blot analysis of CENP-H expression in HeLa whole cell lysate.
sc-22792
CENP-H (FL-247): sc-22792. Western blot analysis of CENP-H expression in non-transfected: sc-117752 (A) and human CENP-H transfected: sc-113785 (B) 293T whole cell lysates.
sc-22792
CENP-H (FL-247): sc-22792. Western blot analysis of CENP-H expression in non-transfected 293T: sc-117752 (A), mouse CENP-H transfected 293T: sc-119163 (B) and Jurkat (C) whole cell lysates.
sc-22792
CENP-H (FL-247): sc-22792. Western blot analysis of CENP-H expression in non-transfected 293T: sc-117752 (A), human CENP-H transfected 293T: sc-112746 (B) and NIH/3T3 (C) whole cell lysates.
sc-22792
CENP-H (FL-247): sc-22792. Western blot analysis of CENP-H expression in non-transfected: sc-117752 (A) and human CENP-H transfected: sc-159480 (B) 293T whole cell lysates and NIH/3T3 nuclear extract (C).
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