CENP-F Background Information A replicated chromosome includes two kinetochores that control chromosome segregation during mitosis. Centromere Protein F, CENP-F (also designated mitosin) is a nuclear matrix kinetochore protein that plays a role in mitotic events. In HeLa cells, CENP-F gradually accumulates in the cell cycle, and like CENP-E is preferentially expressed during mitosis where it mediates the G(2) to M phase checkpoint. Upon completion of mitosis, CENP-F is rapidly degraded. CENP-F consists of two coil domains that flank a central flexible core and contains a P-loop (ADIPTGKT) nucleotide binding site in its globular carboxy terminus.
CENP-F (H-260) Product Citations
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CENP-F (H-260)
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CENP-F (H-300): sc-22791. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear localization.
CENP-F (H-260): sc-22791. Immunoperoxidase staining of formalin fixed, paraffin-embedded human lateral ventricle tissue showing nuclear staining of neuronal and non-neuronal cells at low (A) and high (B) magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.
CENP-F (H-260): sc-22791. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear localization.
