CENP-A Background Information A replicated chromosome includes two kinetochores that control chromosome segregation during mitosis. Centromere protein-A (CENP-A) is a Histone H3-like protein that contains a C-terminal H3-like domain, required for centro-mere localization of CENP-A, and an antigenic N-terminal domain. CENP-A, originally isolated from HeLa cells, is essential for kinetochore targeting of CENP-C. In the presence of DNA, CENP-A forms an octameric complex with histones H4, H2A and H2B. CENP-A specifically localizes to active centromeres and is a component of specialized centromeric nucleosomes, on which kinetochores are assembled. CENP-A is essential for nucleosomal packaging of centromeric DNA at interphase and functions as a centromere formation marker on the chromosome.
CENP-A (H-50) Product Citations
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CENP-A (H-50)
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CENP-A (H-50): sc-22787. Western blot analysis of CENP-A expression in non-transfected: sc-117750 (A) and human CENP-A transfected: sc-110448 (B) CHO whole cell lysates.
CENP-A (H-50): sc-22787. Western blot analysis of CENP-A expression in non-transfected: sc-110760 (A) and human CENP-A transfected: sc-110471 (B) 293 whole cell lysates.
