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- rabbit polyclonal IgG, 200 µg/ml
- epitope corresponding to amino acids 1-300 of TACC3 of human origin
- recommended for detection of TACC3 of human and, to a lesser extent, mouse and rat origin by WB, IP, IF and ELISA
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Ordering InformationProduct Citations
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| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
TACC3 |
10460 |
4p16.3 |
NM_006342 |
Q9Y6A5
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605303 |
| Mouse |
Tacc3 |
21335 |
5 B2 |
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Q9JJ11
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N/A |
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TACC3 Background Information
TACC1 (transforming acidic coiled coil gene 1) is one of three TACC family members, which are thought to be involved in breast tumorigenesis. TACC1 is located on 8p11, in a chromosomal region that is amplified in approximately 15% of all breast tumor samples. The short arm of chromosome 8 also contains FGFR1, whose expression is enhanced in most breast cancer tumors. TACC family members TACC1, TACC2, and TACC3 map very closely to the corresponding FGFR1, FGFR2, FGFR3 genes on chromosomes 8, 10, and 4. Subsequently, since they are phylogenetically related, it is proposed that TACC and FGFR have similar roles in cell growth and differentiation. Also, TACC1 contains a conserved C-terminal region as in the Drosophila homolog D-TACC. D-TACC has been shown to be necessary for normal spindle function, and the mammalian TACC proteins appears to interact with centrosomes and microtubules in a similar manner.
| TACC3 (H-300) Product Citations |
See how others have used TACC3 (H-300): sc-22773 antibody and or TACC3 (H-300) antibody conjugates.
3 total citations Loading citations.
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TACC3 (H-300)
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TACC3 (H-300): sc-22773. Western blot analysis of TACC3 expression in HeLa whole cell lysate.
TACC3 (H-300): sc-22773. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.
TACC3 (H-300): sc-22773. Western blot analysis of TACC3 expression in non-transfected 293T: sc-117752 (A), human TACC3 transfected 293T: sc-111721 (B) and HeLa (C) whole cell lysates. TACC3 (H-300): sc-22773. Western blot analysis of TACC3 expression in non-transfected 293T: sc-117752 (A), mouse TACC3 transfected 293T: sc-123890 (B) and Jurkat (C) whole cell lysates. TACC3 (H-300): sc-22773. Western blot analysis of TACC3 expression in non-transfected 293T: sc-117752 (A), mouse TACC3 transfected 293T: sc-123891 (B) and HeLa (C) whole cell lysates. |
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