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home » Signaling Intermediates » gammaGCS Antibody / gammaGCS Antibodies » γ-GCSm (FL-274): sc-22754

γ-GCSm (FL-274) Antibody: sc-22754

  |  Datasheet
  • rabbit polyclonal IgG, 200 µg/ml
  • epitope corresponding to amino acids 1-274 representing full length γ-GCSm of human origin
  • recommended for detection of γ-GCSm of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including bovine and porcine
 
Additional gammaGCS Antibodies ...
 
Ordering InformationProduct Citations
Recommended Support Products:
(click button of application of choice)
WB   IP   IF   IHC(P)   siRNA  
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human GCLM 2730 1p22.1 NM_002061 P48507
 601176
Mouse Gclm 14630 3 G1 O09172
 N/A
 
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
γ-GCSm (FL-274) sc-22754 200 µg/ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
γ-GCSm siRNA (h) sc-40602 10 µM $258
γ-GCSm siRNA (m) sc-40603 10 µM $258
γ-GCSm siRNA (h) sc-40602-PR 10 µM $23
γ-GCSm (m)-PR sc-40603-PR 10 µM $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
γ-GCSm shRNA Plasmid (h) sc-40602-SH 20 µg $520
γ-GCSm shRNA Plasmid (m) sc-40603-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
γ-GCSm shRNA (h) Lentiviral Particles sc-40602-V 200 µl $625
γ-GCSm shRNA (m) Lentiviral Particles sc-40603-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
A549 Cell Lysate sc-2413 500 µg/200 µl $104
MOLT-4 Cell Lysate sc-2233 500 µg/200 µl $104
K-562 Whole Cell Lysate sc-2203 500 µg/200 µl $104
mouse liver extract sc-2256 500 µg/200 µl $104
K-562 nuclear extract sc-2130 1000 µg $143

γ-GCSm Background Information
Gamma-glutamylcysteine synthetase (©-GCS) is the rate limiting enzyme for glutathione (L-gamma-glutamyl-L-cysteinylglycine, GSH) synthesis. GSH is ubiquitous in mammalian cells as a vital intra- and extracellular protective antioxidant. ©-GCS is a heterodimer of a heavy catalytic subunit and a light regulatory subunit that is responsive to inflammation, phenolic antioxidants, heat shock, oxidants and cytokines. The human gamma-GCS gene encoding the 367 amino acid catalytic subunit maps to chromosome 6p12. The human ©-GCS gene encoding the regulatory subunit maps to chromosome 1p22-p21. The two subunits of ©-GCS form a heterodimeric zinc metalloprotein that gains activity through formation of a reversible disulfide bond.

γ-GCSm (FL-274) Product Citations
See how others have used γ-GCSm (FL-274): sc-22754 antibody and or γ-GCSm (FL-274) antibody conjugates.


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γ-GCSm (FL-274)
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sc-22754
γ-GCSm (FL-274): sc-22754. Western blot analysis of γ-GCSm regulatory subunit expression in A549 (A), MOLT-4 (B) and K-562 (C) whole cell lysates.
sc-22754
γ-GCSm (FL-274): sc-22754. Immunofluorescence staining of methanol-fixed A549 cells showing cytoplasmic llocalization.
sc-22754
γ-GCSm (FL-274): sc-22754. Immunoperoxidase staining of formalin fixed, paraffin-embedded human duodenum tissue showing cytoplasmic staining of glandular cells at low (A) and high (B) magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.
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