goat polyclonal IgG, 200 µg/ml; also available as rabbit IgG, 200 µg/ml, sc-22538-R
epitope mapping at the C-terminus of OSX of human origin
recommended for detection of OSX of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine and bovine
TransCruz reagent for Gel Supershift and ChIP applications, sc-22538 X, 200 µg/0.1 ml
OSX Background Information Osterix (OSX) is a zinc finger-containing transcriptional activator that is distinctly expressed in all developing bones and is important for osteoblast differentiation. In particular, OSX is implicated in the differentiation of osteo-blasts, which are the specialized cells of bone formation. OSX is a nuclear protein that binds to GC box promoters elements and activates mRNA synthesis from genes containing functional recognition sites. The periosteal and mesenchymal cells of the membranous skeletal elements of OSX- mice fail to differentiate into osteoblasts. Subsequently, the mesenchymal cells of OSX- mice fail to deposit bone matrix and do not form bone. Cox-2 deficiency correlates with a decrease in OSX expression, suggesting that Cox-2 may induce OSX to mediate skeletal repair.
OSX (M-15) Product Citations
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OSX (M-15)
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OSX (M-15): sc-22538. Western blot analysis of OSX expression in HOS whole cell lysate.
