p-gp130 (Ser 782)-R Antibody sc-22346-R

santa cruz biotechnology, inc.

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p-gp130 (Ser 782)-R Antibody: sc-22346-R	\| Datasheet

rabbit polyclonal IgG, 200 µg/ml
epitope corresponding to phosphorylated Ser 782 of gp130 of human origin
recommended for detection of Ser 782 phosphorylated gp130 of mouse, rat and human origin by WB, IP and IF; also reactive with additional species, including avian
blocking peptide, sc-22346 P

Additional gp130 Antibodies ...

Ordering Information

Recommended Support Products:

(click button of application of choice)

WB IP IF siRNA

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Ordering Information

Product Name	Catalog #	Unit	Price
p-gp130 (Ser 782) P	sc-22346 P (peptide)	100 µg/0.5 ml	$61
p-gp130 (Ser 782)-R	sc-22346-R	200 µg/ml	$279
Lambda Phosphatase	sc-200312	100,000 units	$462
Lambda Phosphatase	sc-200312A	20,000 units	$116

siRNA Gene Silencers (click product name for more information)

Product Name	Catalog #	Unit	Price
gp130 siRNA (h)	sc-29333	10 µM	$258
gp130 siRNA (m)	sc-35502	10 µM	$258
gp130 (h)-PR	sc-29333-PR	10 µM	$23
gp130 (m)-PR	sc-35502-PR	10 µM	$23

shRNA Plasmids (click product name for more information)

Product Name	Catalog #	Unit	Price	Qty	Add	Favorites
gp130 shRNA Plasmid (h)	sc-29333-SH	20 µg	$520
gp130 shRNA Plasmid (m)	sc-35502-SH	20 µg	$520

shRNA Lentiviral Particles (click product name for more information)

Product Name	Catalog #	Unit	Price	Qty	Add	Favorites
gp130 shRNA (h) Lentiviral Particles	sc-29333-V	200 µl	$625
gp130 shRNA (m) Lentiviral Particles	sc-35502-V	200 µl	$625

WB Positive Control Cell Lysate (click product name for more information)

Product Name	Catalog #	Unit	Price	Qty	Add	Favorites
HeLa Whole Cell Lysate	sc-2200	500 µg/200 µl	$104

gp130 Background Information
IL-6 activates intracellular signaling by binding to IL-6R (the IL-6 receptor), which subsequently associates with a second protein, known as gp130. The active signaling complex consists of at minimum IL-6, IL-6R and a dimer of two gp130 proteins that are linked by a disulfide bond. The second subunit of the IL-6 complex, gp130, also functions as a component of several additional receptor complexes, including leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF) and IL-11. The major phosphorylation site of human gp130 is located immediately N-terminal to the di-leucine motif of gp130, which regulates the internalization of the receptor. Phospho-rylation of this site, Ser 782, regulates cell surface expression of the receptor polypeptide.

p-gp130 (Ser 782)-R

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p-gp130 (Ser 782): sc-22346. Western blot analysis of gp130 phosphorylation in HeLa whole cell lysate.

p-gp130 (Ser 782)-R: sc-22346-R. Immunofluorescence staining of methanol-fixed HeLa cells showing membrane localization.

p-gp130 (Ser 782)-R: sc-22346-R. Western blot analysis of gp130 phosphorylation in untreated (A) and lambda protein phosphatase treated (B) NIH/3T3 whole cell lysates.

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p-gp130 (Ser 782)-R Antibody: sc-22346-R