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p-PAM Antibody (Ser 949)-R: sc-22263-R

 |  Datasheet

(Based on data analysis)
  • p-PAM (Ser 949)-R Antibody is a rabbit polyclonal IgG provided at 200 µg/ml
  • recommended for detection of Ser 949 phosphorylated PAM of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
  • blocking peptide, sc-22263 P
 

See additional PAM Antibodies.

Ordering Information
Recommended Support Products:
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WB   IF   siRNA  
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 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
p-PAM (Ser 949) P sc-22263 P
(peptide)
 100 µg/0.5 ml $61
p-PAM (Ser 949)-R Antibody sc-22263-R 200 µg/ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
PAM siRNA (h) sc-106802 10 µM $258
PAM siRNA (m) sc-155926 10 µM $258
PAM (h)-PR sc-106802-PR 10 µM, 20 µl $23
PAM (m)-PR sc-155926-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
PAM shRNA Plasmid (h) sc-106802-SH 20 µg $520
PAM shRNA Plasmid (m) sc-155926-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
PAM shRNA (h) Lentiviral Particles sc-106802-V 200 µl $625
PAM shRNA (m) Lentiviral Particles sc-155926-V 200 µl $625
 WB Positive Control Cell Lysate (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
MIA PaCa-2 Cell Lysate sc-2285 500 µg/200 µl $104

Peptidylglycine alpha-amidating monooxygenase (PAM) catalyzes the two-step formation of bioactive alpha-amidated neural and endocrine peptides from their glycine-extended precursors. PAM is a bifunctional protein that contains a peptidyl-glycine alpha-hydroxylating monooxygenase and a peptidyl-alpha-hydroxyglycine alpha-amidating lyase catalytic domains. Tissue-specific alternative splicing and endoproteo-lysis generate both soluble and integral membrane mono- and bifunctional PAM proteins. PAM is highly expressed in ovary, testis, lung, heart septum, anterior pituitary and hypothalamus, and to a lesser extent in liver, ventricle, atrium and neuro-intermediate lobe. The 3’-untranslated region of PAM mRNA has a novel 20-nucleotide cis element, which is able to interact with cellular cytosolic protease-sensitive factor(s). The cytosolic domain of the PAM protein contains multiple signals determining its subcellular localization. PAM interacts with three related cytosolic proteins, designated P-CIPs (PAM cytosolic interactor proteins). P-CIP2 is a protein kinase that phosphorylates PAM at serine 949. Phosphorylation of PAM in the cytosolic domain of PAM plays a critical role in the trafficking of PAM. PAM in rat sciatic nerves is proteolytically processed during the axonal transport of secretion granules.