Molecular structure of Tubulin Polymerization Inhibitor, CAS Number: 564468-51-5
Tubulin Polymerization Inhibitor (CAS 564468-51-5)
Application:
Tubulin Polymerization Inhibitor is an antimicrotubule agent
CAS Number:
564468-51-5
Molecular Weight:
328.37
Molecular Formula:
C22H16O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Tubulin Polymerization Inhibitor is a low molecular weight, cell-permeable, benzylidene-anthracenone antimicrotubule agent that exhibits potent antitumor activity (IC50 = 20 and 50 nM in inhibiting tumor cell growth in K562 and SKOV3 cells, respectively) comparable to other commonly used antitumor agents. Unlike Paclitaxel , Vinblastine , or Vincristine , it does not function as a substrate for Pgp-170 and exhibits cytotoxic effects towards tumor cell lines with various MDR resistance phenotypes. It is shown to interact with tubulin at the Colchicine, but not the Vinblastine, binding site.
Tubulin Polymerization Inhibitor (CAS 564468-51-5) References
- 10-(2-oxo-2-phenylethylidene)-10H-anthracen-9-ones as highly active antimicrotubule agents: synthesis, antiproliferative activity, and inhibition of tubulin polymerization. | Prinz, H., et al. 2009. J Med Chem. 52: 1284-94. PMID: 19220018
- Natural-Product-Inspired Discovery of Trimethoxyphenyl-1,2,4-triazolosulfonamides as Potent Tubulin Polymerization Inhibitors. | Rao, VK., et al. 2024. ChemMedChem. 19: e202300562. PMID: 37975190
- 3-aryl-4-(3,4,5-trimethoxyphenyl)pyridines inhibit tubulin polymerisation and act as anticancer agents. | Wang, C., et al. 2024. J Enzyme Inhib Med Chem. 39: 2286939. PMID: 38083880
- Microtubule destabilising activity of selected 7-methoxy-2-phenylbenzo[b]furan derivative against primary and metastatic melanoma cells. | Perużyńska, M., et al. 2024. Eur J Pharmacol. 964: 176308. PMID: 38142850
- epi-Magnolin, a tetrahydrofurofuranoid lignan from the oleo-gum resin of Commiphora wightii, as inhibitor of pancreatic cancer cell proliferation, in-vitro and in-silico study. | Abd El-Razek, MH., et al. 2024. J Biomol Struct Dyn. 1-13. PMID: 38265952
- Design and biological evaluation of dual tubulin/HDAC inhibitors based on millepachine for treatment of prostate cancer. | Xie, S., et al. 2024. Eur J Med Chem. 268: 116301. PMID: 38452727
- Genetic imputation of kidney transcriptome, proteome and multi-omics illuminates new blood pressure and hypertension targets. | Xu, X., et al. 2024. Nat Commun. 15: 2359. PMID: 38504097
- Aluminum-Catalyzed Intramolecular Vinylation of Arenes by Vinyl Cations. | Lin, W., et al. 2024. Org Lett. 26: 3267-3272. PMID: 38574281
- Design, concise synthesis and evaluation of novel amide-based combretastatin A-4 analogues as potent tubulin inhibitors. | Ma, Y., et al. 2024. Bioorg Med Chem Lett. 108: 129816. PMID: 38806101
Inhibitor of:
Tubulin.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Tubulin Polymerization Inhibitor, 5 mg | sc-222377 | 5 mg | $140.00 |